Thrombotic microangiopathy as first manifestation of acute human immunodeficiency virus infection: a case report and review of the literature

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dc.contributor.authorSarmiento Maldonado, Mauricio
dc.contributor.authorBalcells Marty, María Elvira
dc.contributor.authorRamírez Villanueva, Pablo Antonio
dc.date.accessioned2019-10-17T13:20:53Z
dc.date.available2019-10-17T13:20:53Z
dc.date.issued2016
dc.date.updated2019-10-14T19:02:15Z
dc.description.abstractAbstract Background We present the case of a patient with acute human immunodeficiency virus infection and a thrombotic microangiopathy as the first clinical manifestation, a presentation that has not, to the best of our knowledge, been previously reported. Case presentation A 35-year-old Bolivian man presented with epistaxis and thrombocytopenia. We found microangiopathic anemia, lymphopenia, elevated lactate dehydrogenase, progressive acute renal failure, negative direct antiglobulin test, and normal activity of ADAMTS13. An human immunodeficiency virus ELISA test was negative, with an human immunodeficiency virus viral load of 10,000,000 RNA copies/mL. Antiretroviral therapy and three sessions of therapeutic plasma exchange were able to control thrombotic microangiopathy. Conclusions Hematologic manifestations of human immunodeficiency virus infection are frequent. However, the debut of acute human immunodeficiency virus infection with thrombotic microangiopathy is a rare event. A high index of suspicion and early treatment is required.
dc.fuente.origenBiomed Central
dc.identifier.citationJournal of Medical Case Reports. 2016 Jun 07;10(1):152
dc.identifier.doi10.1186/s13256-016-0938-z
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/26620
dc.issue.numeroNo. 152
dc.language.isoen
dc.nota.accesoContenido completo
dc.pagina.final3
dc.pagina.inicio1
dc.revistaJournal of Medical Case Reportses_ES
dc.rightsacceso abierto
dc.rights.holderSarmiento et al.
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.subject.otherAnemia hemolíticaes_ES
dc.subject.otherAnemia hemolítica - Terapiaes_ES
dc.subject.otherEnfermedades infecciosases_ES
dc.subject.otherInfecciones por VIHes_ES
dc.titleThrombotic microangiopathy as first manifestation of acute human immunodeficiency virus infection: a case report and review of the literaturees_ES
dc.typeartículo
dc.volumenVol. 10
sipa.codpersvinculados167160
sipa.codpersvinculados7462
sipa.codpersvinculados1242
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