Contribution of hypoxia inducible factor-1 during viral infections

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dc.catalogadorgjm
dc.contributor.authorReyes Muñoz, Antonia Paz
dc.contributor.authorCorrales Bonilla, Nicolás
dc.contributor.authorGálvez Arriagada, Nicolás Marcelo Salvador
dc.contributor.authorBueno Ramírez, Susan
dc.contributor.authorKalergis Parra, Alexis Mikes
dc.contributor.authorGonzález Muñoz, Pablo Alberto
dc.date.accessioned2024-01-30T15:23:29Z
dc.date.available2024-01-30T15:23:29Z
dc.date.issued2020
dc.description.abstractHypoxia-inducible factor 1 (HIF-1) is a transcription factor that plays critical roles during the cellular response to hypoxia. Under normoxic conditions, its function is tightly regulated by the degradation of its alpha subunit (HIF-1α), which impairs the formation of an active heterodimer in the nucleus that otherwise regulates the expression of numerous genes. Importantly, HIF-1 participates in both cancer and infectious diseases unveiling new therapeutic targets for those ailments. Here, we discuss aspects related to the activation of HIF-1, the effects of this transcription factor over immune system components, as well as the involvement of HIF-1 activity in response to viral infections in humans. Although HIF-1 is currently being assessed in numerous clinical settings as a potential therapy for different diseases, up to date, there are no clinical studies evaluating the pharmacological modulation of this transcription factor as a possible new antiviral treatment. However, based on the available evidence, clinical trials targeting this molecule are likely to occur soon. In this review we discuss the role of HIF-1 in viral immunity, the modulation of HIF-1 by different types of viruses, as well as the effects of HIF-1 over their life cycle and the potential use of HIF-1 as a new target for the treatment of viral infections.
dc.fechaingreso.objetodigital2024-04-11
dc.fuente.origenORCID
dc.identifier.doi10.1080/21505594.2020.1836904
dc.identifier.urihttps://doi.org/10.1080/21505594.2020.1836904
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/81055
dc.identifier.wosidWOS:000582948600001
dc.information.autorucFacultad de Ciencias Biológicas; Reyes Muñoz, Antonia Paz; S/I; 247419
dc.information.autorucFacultad de Ciencias Biológicas; Corrales Bonilla Nicolas; S/I; 247402
dc.information.autorucFacultad de Ciencias Biológicas; Gálvez Arriagada, Nicolás Marcelo Salvador; 0000-0003-2046-7882; 215440
dc.information.autorucFacultad de Ciencias Biológicas; Bueno Ramírez, Susan; 0000-0002-7551-8088; 113541
dc.information.autorucFacultad de Ciencias Biológicas; Kalergis Parra, Alexis Mikes; 0000-0001-7622-5263; 90610
dc.information.autorucFacultad de Ciencias Biológicas; González Muñoz, Pablo Alberto; 0000-0001-7709-6870; 15616
dc.language.isoen
dc.nota.accesoContenido completo
dc.rightsacceso abierto
dc.subjectHypoxia
dc.subjectNormoxia
dc.subjectRNA viruses
dc.subjectDNA viruses
dc.subjectVirus life cycle
dc.subjectViral treatment
dc.subject.ddc570
dc.subject.deweyBiologíaes_ES
dc.subject.ods03 Good health and well-being
dc.subject.odspa03 Salud y bienestar
dc.titleContribution of hypoxia inducible factor-1 during viral infections
dc.typeartículo
sipa.codpersvinculados247419
sipa.codpersvinculados247402
sipa.codpersvinculados215440
sipa.codpersvinculados113541
sipa.codpersvinculados90610
sipa.codpersvinculados15616
sipa.trazabilidadORCID;2024-01-15
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