Lithium Enhances Hippocampal Glucose Metabolism in an In Vitro Mice Model of Alzheimer's Disease

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dc.contributor.authorGherardelli, Camila
dc.contributor.authorCisternas, Pedro
dc.contributor.authorInestrosa, Nibaldo C.
dc.date.accessioned2025-01-20T21:03:22Z
dc.date.available2025-01-20T21:03:22Z
dc.date.issued2022
dc.description.abstractImpaired cerebral glucose metabolism is an early event that contributes to the pathogenesis of Alzheimer's disease (AD). Importantly, restoring glucose availability by pharmacological agents or genetic manipulation has been shown to protect against A beta toxicity, ameliorate AD pathology, and increase lifespan. Lithium, a therapeutic agent widely used as a treatment for mood disorders, has been shown to attenuate AD pathology and promote glucose metabolism in skeletal muscle. However, despite its widespread use in neuropsychiatric disorders, lithium's effects on the brain have been poorly characterized. Here we evaluated the effect of lithium on glucose metabolism in hippocampal neurons from wild-type (WT) and APPSwe/PS1 Delta E9 (APP/PS1) mice. Our results showed that lithium significantly stimulates glucose uptake and replenishes ATP levels by preferential oxidation of glucose through glycolysis in neurons from WT mice. This increase was also accompanied by a strong increase in glucose transporter 3 (Glut3), the major carrier responsible for glucose uptake in neurons. Similarly, using hippocampal slices from APP-PS1 mice, we demonstrate that lithium increases glucose uptake, glycolytic rate, and the ATP:ADP ratio in a process that also involves the activation of AMPK. Together, our findings indicate that lithium stimulates glucose metabolism and can act as a potential therapeutic agent in AD.
dc.fuente.origenWOS
dc.identifier.doi10.3390/ijms23158733
dc.identifier.eissn1422-0067
dc.identifier.urihttps://doi.org/10.3390/ijms23158733
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/93144
dc.identifier.wosidWOS:000839363500001
dc.issue.numero15
dc.language.isoen
dc.revistaInternational journal of molecular sciences
dc.rightsacceso restringido
dc.subjectlithium
dc.subjectglucose
dc.subjectmetabolism
dc.subjectAlzheimer's disease
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleLithium Enhances Hippocampal Glucose Metabolism in an In Vitro Mice Model of Alzheimer's Disease
dc.typeartículo
dc.volumen23
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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