Distribution of angiotensin-(1-7) and ACE2 in human placentas of normal and pathological pregnancies
dc.contributor.author | Valdes, G | |
dc.contributor.author | Neves, LAA | |
dc.contributor.author | Anton, L | |
dc.contributor.author | Corthorn, J | |
dc.contributor.author | Chacon, C | |
dc.contributor.author | Germain, AM | |
dc.contributor.author | Merrill, DC | |
dc.contributor.author | Ferrario, CM | |
dc.contributor.author | Sarao, R | |
dc.contributor.author | Penninger, J | |
dc.contributor.author | Brosnihan, KB | |
dc.date.accessioned | 2024-01-10T12:38:23Z | |
dc.date.available | 2024-01-10T12:38:23Z | |
dc.date.issued | 2006 | |
dc.description.abstract | This work was designed to study the expression of the vasodilator peptide angiotensin-(1-7) [Ang-(1-7)] and its generating enzyme (ACE2) in the uteroplacental interface. Placentas were obtained from 11 early pregnancy failures (5 miscarriages and 6 ectopic pregnancies), 15 normotensive, and 10 preeclamptic gestations. In placental villi, the main sites of immunocytochemical expression of Ang-(1-7) and ACE2 were the syncytiotrophoblast, cytotrophoblast, endothelium and vascular smooth muscle of primary and secondary villi. Syncitial Ang-(1-7) expression in samples obtained from miscarriages and ectopic pregnancies was increased compared to normal term pregnancy [2.0 (2.0-2.25 for the 25 and 75% interquartile range) vs 1.3 (1.0-1.9), p < 0.01]. In the maternal stroma, Ang-(1-7) and ACE2 were expressed in the invading and intravascular trophoblast and in decidual cells in all 3 groups. Ang-(1-7) and ACE2 staining was also found in arterial and venous endothelium and smooth muscle of the umbilical cord. The expression of Ang-(1-7) and ACE2 was similar in samples obtained from normal term or preeclamptic pregnancies, except for increased expression of ACE2 in umbilical arterial endothelium in preeclarmpsia [0.5 (0.5-0.8) vs 0.0 (0.0-0.0), p < 0.01]. The uteroplacental location of Ang-(1-7) and ACE2 in pregnancy suggests an autocrine function of Ang-(1-7) in the vasoactive regulation that characterizes placentation and established pregnancy. (c) 2005 Elsevier Ltd. All rights reserved. | |
dc.description.funder | NHLBI NIH HHS | |
dc.description.funder | NICHD NIH HHS | |
dc.description.funder | NATIONAL HEART, LUNG, AND BLOOD INSTITUTE | |
dc.fechaingreso.objetodigital | 05-04-2024 | |
dc.format.extent | 8 páginas | |
dc.fuente.origen | WOS | |
dc.identifier.doi | 10.1016/j.placenta.2005.02.015 | |
dc.identifier.eissn | 1532-3102 | |
dc.identifier.issn | 0143-4004 | |
dc.identifier.pubmedid | MEDLINE:16338465 | |
dc.identifier.uri | https://doi.org/10.1016/j.placenta.2005.02.015 | |
dc.identifier.uri | https://repositorio.uc.cl/handle/11534/77035 | |
dc.identifier.wosid | WOS:000234728000011 | |
dc.information.autoruc | Medicina;Valdés G;S/I;98654 | |
dc.issue.numero | 2-3 | |
dc.language.iso | en | |
dc.nota.acceso | Contenido parcial | |
dc.pagina.final | 207 | |
dc.pagina.inicio | 200 | |
dc.publisher | W B SAUNDERS CO LTD | |
dc.revista | PLACENTA | |
dc.rights | acceso restringido | |
dc.subject | hypertension | |
dc.subject | pregnancy | |
dc.subject | angiotensin-(1-7) | |
dc.subject | preeclampsia | |
dc.subject | renin angiotensin system | |
dc.subject | angiotensin converting enzyme 2 | |
dc.subject | ENDOTHELIAL GROWTH-FACTOR | |
dc.subject | NITRIC-OXIDE SYNTHASE | |
dc.subject | ENZYME-RELATED CARBOXYPEPTIDASE | |
dc.subject | CONVERTING ENZYME | |
dc.subject | TISSUE KALLIKREIN | |
dc.subject | HYPERTENSIVE-RATS | |
dc.subject | OPPOSING ACTIONS | |
dc.subject | LATE-GESTATION | |
dc.subject | BRADYKININ | |
dc.subject | LOCALIZATION | |
dc.subject.ods | 03 Good Health and Well-being | |
dc.subject.odspa | 03 Salud y bienestar | |
dc.title | Distribution of angiotensin-(1-7) and ACE2 in human placentas of normal and pathological pregnancies | |
dc.type | artículo | |
dc.volumen | 27 | |
sipa.codpersvinculados | 98654 | |
sipa.index | WOS | |
sipa.index | Scopus | |
sipa.trazabilidad | Carga SIPA;09-01-2024 |
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