Association of metabolic flexibility indexes after an oral glucose tolerance test with cardiometabolic risk factors

dc.catalogadorvdr
dc.contributor.authorAlcantara, Juan M. A.
dc.contributor.authorGalgani Fuentes, José
dc.date.accessioned2024-10-15T16:18:42Z
dc.date.available2024-10-15T16:18:42Z
dc.date.issued2023
dc.description.abstract© 2023, The Author(s), under exclusive licence to Springer Nature Limited.Background & aims: Metabolic flexibility (MetF) is considered a metabolic health biomarker, as excess body weight is associated with lower MetF. We aimed to identify whether MetF indexes were associated with cardiometabolic risk factors before and after adjustment for body size-related factors (body weight, fat-free mass, and resting metabolic rate). Methods: We studied 51 participants (55% women; 33.6 ± 8.7 years; 26.3 ± 3.8 kg/m²) who consumed a 75-g glucose load. We measured gas exchange before (fasting) and for 3 h after glucose ingestion. MetF indexes were assessed, including the change after each hour and the 3-hour incremental area under the curve (iAUC) in respiratory exchange ratio (RER). These indexes were then related to cardiometabolic risk factors before and after adjusting for body size-related factors. Results: MetF indexes correlated with each other (r ≥ 0.51; P < 0.001) and related to body weight (adjusted R2 ≥ 0.09; P < 0.03). A similar pattern was noted for fat-free mass and resting metabolic rate. MetF, regardless of the index, was not related to cardiometabolic risk factors except to BMI and high-density lipoprotein-cholesterol (HDL-C). The association between BMI and MetF disappeared after adjusting for body size-related factors. Similar adjustments did not modify the association between HDL-C and MetF, especially when approached by the change in RER after the first hour (adjusted R2 = 0.20–0.22; all P < 0.02). Conclusions: Inter-individual body size differences fully accounted for the associations between BMI and MetF. However, variability in body size-related factors appeared less relevant in affecting the associations of other cardiometabolic risk factors with MetF.
dc.description.funderCONICYT/FONDECYT
dc.description.funderMCIN
dc.description.funderAEI
dc.description.funderANID
dc.fechaingreso.objetodigital2024-10-15
dc.format.extent7 páginas
dc.fuente.origenScopus
dc.fuente.origenORCID
dc.identifier.doi10.1038/s41430-023-01373-w
dc.identifier.issn1476-5640
dc.identifier.scopusidSCOPUS_ID:85180205599
dc.identifier.urihttps://doi.org/10.1038/s41430-023-01373-w
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/88236
dc.identifier.wosidWOS:001127195400001
dc.information.autorucEscuela de Medicina; Galgani Fuentes, José; 0000-0001-9793-8561; 1011272
dc.language.isoen
dc.nota.accesocontenido parcial
dc.pagina.final186
dc.pagina.inicio180
dc.revistaEuropean Journal of Clinical Nutrition
dc.rightsacceso restringido
dc.subject.ods03 Good health and well-being
dc.subject.odspa03 Salud y bienestar
dc.titleAssociation of metabolic flexibility indexes after an oral glucose tolerance test with cardiometabolic risk factors
dc.typeartículo
dc.volumen78
sipa.codpersvinculados1011272
sipa.trazabilidadSCOPUS;2023-12-31
sipa.trazabilidadORCID;2024-10-14
Files
Original bundle
Now showing 1 - 1 of 1
Loading...
Thumbnail Image
Name:
s41430-023-01373-w.pdf
Size:
853.61 KB
Format:
Adobe Portable Document Format
Description: