Patients recovering from COVID-19 who presented with anosmia during their acute episode have behavioral, functional, and structural brain alterations

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dc.contributor.authorKausel, Leonie
dc.contributor.authorFigueroa-Vargas, Alejandra
dc.contributor.authorZamorano, Francisco
dc.contributor.authorStecher, Ximena
dc.contributor.authorAspe-Sanchez, Mauricio
dc.contributor.authorCarvajal-Paredes, Patricio
dc.contributor.authorMarquez-Rodriguez, Victor
dc.contributor.authorMartinez-Molina, Maria Paz
dc.contributor.authorRoman, Claudio
dc.contributor.authorSoto-Fernandez, Patricio
dc.contributor.authorValdebenito-Oyarzo, Gabriela
dc.contributor.authorManterola, Carla
dc.contributor.authorUribe-San-Martin, Reinaldo
dc.contributor.authorSilva, Claudio
dc.contributor.authorHenriquez-Ch, Rodrigo
dc.contributor.authorAboitiz, Francisco
dc.contributor.authorPolania, Rafael
dc.contributor.authorGuevara, Pamela
dc.contributor.authorMunoz-Venturelli, Paula
dc.contributor.authorSoto-Icaza, Patricia
dc.contributor.authorBilleke, Pablo
dc.date.accessioned2025-01-20T16:10:45Z
dc.date.available2025-01-20T16:10:45Z
dc.date.issued2024
dc.description.abstractPatients recovering from COVID-19 commonly exhibit cognitive and brain alterations, yet the specific neuropathological mechanisms and risk factors underlying these alterations remain elusive. Given the significant global incidence of COVID-19, identifying factors that can distinguish individuals at risk of developing brain alterations is crucial for prioritizing follow-up care. Here, we report findings from a sample of patients consisting of 73 adults with a mild to moderate SARS-CoV-2 infection without signs of respiratory failure and 27 with infections attributed to other agents and no history of COVID-19. The participants underwent cognitive screening, a decision-making task, and MRI evaluations. We assessed for the presence of anosmia and the requirement for hospitalization. Groups did not differ in age or cognitive performance. Patients who presented with anosmia exhibited more impulsive alternative changes after a shift in probabilities (r = - 0.26, p = 0.001), while patients who required hospitalization showed more perseverative choices (r = 0.25, p = 0.003). Anosmia correlated with brain measures, including decreased functional activity during the decision-making task, thinning of cortical thickness in parietal regions, and loss of white matter integrity. Hence, anosmia could be a factor to be considered when identifying at-risk populations for follow-up.
dc.description.funderAgencia Nacional de Investigacin y Desarrollo
dc.fuente.origenWOS
dc.identifier.doi10.1038/s41598-024-69772-y
dc.identifier.issn2045-2322
dc.identifier.urihttps://doi.org/10.1038/s41598-024-69772-y
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/90228
dc.identifier.wosidWOS:001292795600002
dc.issue.numero1
dc.language.isoen
dc.revistaScientific reports
dc.rightsacceso restringido
dc.subjectSARS-CoV-2
dc.subjectLong-term COVID-19
dc.subjectDecision-making
dc.subjectMRI
dc.subjectDTI
dc.subjectCognitive impairments
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titlePatients recovering from COVID-19 who presented with anosmia during their acute episode have behavioral, functional, and structural brain alterations
dc.typeartículo
dc.volumen14
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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