Temporospatial changes of kallikrein-like enzymes during the estrous cycle and pregnancy in the rat uterus

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dc.contributor.authorValdes, G
dc.contributor.authorFigueroa, CD
dc.contributor.authorCorthorn, J
dc.date.accessioned2024-01-10T12:43:26Z
dc.date.available2024-01-10T12:43:26Z
dc.date.issued1996
dc.description.abstractWe have recently reported the presence of uterine glandular kallikrein in the rat, its mRNA, and its increase in early gestation. This study describes its immunolocalization, by polyclonal antibodies against rat urinary kallikrein, during the estrous cycle and pregnancy, and identifies three members of the kallikrein family. During the estrous cycle, immunoreactivity, represented by an apical rim in the luminal and glandular epithelium, was greater during proestrus. On Day 5 of gestation, the reaction increased, and on Day 6 staining appeared in the apical and basal pole of some cells, On Day 7, staining was markedly increased in the glandular epithelium at the implantation site, frequently occupying the whole cytoplasm, and displaying great intensity in isolated glandular cells; the epithelium of the implantation chamber showed apical immunoreactivity, while the interimplantation zone had a few faintly stained glands. At this stage, the staining represented expression of two of the enzymes, rK1 and rK7. On Days 9 and 10, the staining disappeared, to reappear on Day 12 in the cells underlying the blood vessels of the central subplacental region. On Days 16 and 21, kallikrein staining surrounded the subendothelium of the sinusoids of the whole decidua basalis. This subplacental reaction represented expression of rK1, rK2, and rK7. This study shows important changes in the immunocytochemical expression of three uterine kallikrein-like enzymes during the reproductive cycle, associated with different hormonal milieus and with local stimulation. The localization of these enzymes is associated with areas involved in implantation, trophoblast penetration, and placental blood flow regulation.
dc.fechaingreso.objetodigital2024-04-30
dc.format.extent10 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1095/biolreprod55.2.236
dc.identifier.issn0006-3363
dc.identifier.pubmedidMEDLINE:8828825
dc.identifier.urihttps://doi.org/10.1095/biolreprod55.2.236
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/77594
dc.identifier.wosidWOS:A1996VE87400002
dc.information.autorucMedicina;Valdés G;S/I;98654
dc.issue.numero2
dc.language.isoen
dc.nota.accesocontenido parcial
dc.pagina.final245
dc.pagina.inicio236
dc.publisherSOC STUDY REPRODUCTION
dc.revistaBIOLOGY OF REPRODUCTION
dc.rightsacceso restringido
dc.subjectINTRAUTERINE GROWTH-RETARDATION
dc.subjectIMMUNOHISTOCHEMICAL LOCALIZATION
dc.subjectPLACENTAL ALTERATIONS
dc.subjectGLANDULAR KALLIKREIN
dc.subjectUTERINE KALLIKREIN
dc.subjectPSEUDOPREGNANT RAT
dc.subjectTISSUE KALLIKREIN
dc.subjectKININ SYSTEM
dc.subjectGENE FAMILY
dc.subjectESTERASE-B
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleTemporospatial changes of kallikrein-like enzymes during the estrous cycle and pregnancy in the rat uterus
dc.typeartículo
dc.volumen55
sipa.codpersvinculados98654
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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