Role of nitric oxide in maternal hemodynamics and hormonal changes in pregnant rats

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dc.contributor.authorSalas, SP
dc.date.accessioned2024-01-10T14:21:35Z
dc.date.available2024-01-10T14:21:35Z
dc.date.issued1998
dc.description.abstractNormal pregnancy is characterized by a significant reduction in total peripheral vascular resistance and decreased presser responsiveness to vasodilator agents. This review will consider whether nitric oxide (NO) contributes to these changes, and whether a deficiency of NO produces a pre-eclampsia bike syndrome. The biosynthesis of NO increases in pregnant animals, as assessed by the raised plasma concentration, urinary excretion and metabolic production rate of guanosine 3',5'-cyclic monophosphate (cGMP), the second messenger of NO. In addition urinary excretion of nitrate, the stable metabolites of NO, increases during pregnancy, paralleling the rise in cGMP. Several studies provide convincing evidence indicating that expression and activity of different NO synthases (NOS) are increased in gravid animals. Acute blockade of NOS causes a dose response increase in blood pressure and reverses the blunted vasopressor response to vasoconstrictor agents. Long-term NOS inhibition produces a pre-eclampsia like syndrome, characterized by maternal hypertension, proteinuria, thrombocytopenia, and renal damage, and lower Litter size and fetal weight. Both acute and chronic responses are reduced when L-arginine, the substrate for NOS, is administered in high doses, indicating that these changes are specific to NO inhibition. In conclusion, present data suggest that a disturbance in NO release may contribute to the pathogenesis of preeclampsia.
dc.format.extent8 páginas
dc.fuente.origenWOS
dc.identifier.issn0716-9760
dc.identifier.pubmedidMEDLINE:9830512
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/79719
dc.identifier.wosidWOS:000076240700016
dc.information.autorucMedicina;Salas SP;S/I;51518
dc.issue.numero3
dc.language.isoen
dc.nota.accesoSin adjunto
dc.pagina.final250
dc.pagina.inicio243
dc.publisherSOCIEDAD BIOLGIA CHILE
dc.revistaBIOLOGICAL RESEARCH
dc.rightsregistro bibliográfico
dc.subjectfetal growth
dc.subjectmaternal hemodynamics
dc.subjectnitric oxide
dc.subjectnitric oxide synthase
dc.subjectpre-eclampsia like syndrome
dc.subjectrat pregnancy
dc.subjectINTRAUTERINE GROWTH-RETARDATION
dc.subjectL-ARGININE
dc.subjectSYSTEMIC HYPERTENSION
dc.subjectSYNTHESIS INHIBITION
dc.subjectENDOTHELIAL-CELLS
dc.subjectSYNTHASE ACTIVITY
dc.subjectUTERUS DECREASES
dc.subjectCHRONIC BLOCKADE
dc.subjectCONSCIOUS RATS
dc.subjectBLOOD-PRESSURE
dc.subject.ods03 Good Health and Well-being
dc.subject.ods05 Gender Equality
dc.subject.odspa03 Salud y bienestar
dc.subject.odspa05 Igualdad de género
dc.titleRole of nitric oxide in maternal hemodynamics and hormonal changes in pregnant rats
dc.typeartículo
dc.volumen31
sipa.codpersvinculados51518
sipa.indexWOS
sipa.indexScielo
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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