Dysconnectivity in Schizophrenia Revisited: Abnormal Temporal Organization of Dynamic Functional Connectivity in Patients With a First Episode of Psychosis

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dc.catalogadoraba
dc.contributor.authorRamirez-Mahaluf, Juan P.
dc.contributor.authorTepper, Angeles
dc.contributor.authorMaria Alliende, Luz
dc.contributor.authorMena, Carlos
dc.contributor.authorCastaneda, Carmen Paz
dc.contributor.authorIruretagoyena, Barbara
dc.contributor.authorNachar, Ruben
dc.contributor.authorReyes-Madrigal, Francisco
dc.contributor.authorLeon-Ortiz, Pablo
dc.contributor.authorMora-Duran, Ricardo
dc.contributor.authorOssandon, Tomas
dc.contributor.authorGonzalez-Valderrama, Alfonso
dc.contributor.authorUndurraga, Juan
dc.contributor.authorDe la Fuente-Sandoval, Camilo
dc.contributor.authorCrossley, Nicolas A.
dc.date.accessioned2024-06-10T21:25:34Z
dc.date.available2024-06-10T21:25:34Z
dc.date.issued2023
dc.description.abstractBackground and Hypothesis Abnormal functional connectivity between brain regions is a consistent finding in schizophrenia, including functional magnetic resonance imaging (fMRI) studies. Recent studies have highlighted that connectivity changes in time in healthy subjects. We here examined the temporal changes in functional connectivity in patients with a first episode of psychosis (FEP). Specifically, we analyzed the temporal order in which whole-brain organization states were visited. Study Design Two case-control studies, including in each sample a subgroup scanned a second time after treatment. Chilean sample included 79 patients with a FEP and 83 healthy controls. Mexican sample included 21 antipsychotic-naive FEP patients and 15 healthy controls. Characteristics of the temporal trajectories between whole-brain functional connectivity meta-states were examined via resting-state functional MRI using elements of network science. We compared the cohorts of cases and controls and explored their differences as well as potential associations with symptoms, cognition, and antipsychotic medication doses. Study Results We found that the temporal sequence in which patients' brain dynamics visited the different states was more redundant and segregated. Patients were less flexible than controls in changing their network in time from different configurations, and explored the whole landscape of possible states in a less efficient way. These changes were related to the dose of antipsychotics the patients were receiving. We replicated the relationship with antipsychotic medication in the antipsychotic-naive FEP sample scanned before and after treatment. Conclusions We conclude that psychosis is related to a temporal disorganization of the brain's dynamic functional connectivity, and this is associated with antipsychotic medication use.
dc.format.extent11 páginas
dc.fuente.origenWOS
dc.fuente.origenORCID
dc.identifier.doi10.1093/schbul/sbac187
dc.identifier.eissn1745-1701
dc.identifier.issn0586-7614
dc.identifier.urihttps://doi.org/10.1093/schbul/sbac187
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/86722
dc.identifier.wosidWOS:000893893900001
dc.issue.numero3
dc.language.isoen
dc.pagina.final716
dc.pagina.inicio706
dc.revistaSchizophrenia Bulletin
dc.rightsacceso restringido
dc.subjectDynamic connectivity
dc.subjectMeta-states
dc.subjectAntipsychotic
dc.subjectSchizophrenia
dc.subjectBrain networks
dc.subjectGraph analysis
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.titleDysconnectivity in Schizophrenia Revisited: Abnormal Temporal Organization of Dynamic Functional Connectivity in Patients With a First Episode of Psychosis
dc.typeartículo
dc.volumen49
sipa.trazabilidadORCID;2024-06-03
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