Benefit of adjuvant 5-fluorouracil based chemotherapy for colon cancer: a retrospective cohort study

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dc.contributor.authorMondaca, Sebastian
dc.contributor.authorVillalon, Constanza
dc.contributor.authorLuis Leal, Jose
dc.contributor.authorZuniga, Alvaro
dc.contributor.authorBellolio, Felipe
dc.contributor.authorPadilla, Oslando
dc.contributor.authorPalma, Silvia
dc.contributor.authorGarrido, Marcelo
dc.contributor.authorNervi, Bruno
dc.date.accessioned2024-01-10T12:04:27Z
dc.date.available2024-01-10T12:04:27Z
dc.date.issued2016
dc.description.abstractBackground: Multiple clinical trials have demonstrated the benefits of adjuvant 5-fluorouracil-based chemotherapy for patients with resectable colon cancer (CC), especially in stage III. Aim: To describe the clinical characteristics of a cohort of CC patients treated at a single university hospital in Chile since 2002, and to investigate if chemotherapy had an effect on survival rates. Material and Methods: Review of a tumor registry of the hospital. Medical records of patients with CC treated between 2002 and 2012 were reviewed. Death certificates from the National Identification Service were used to determine mortality. Overall survival was described using the Kaplan-Meier method. A multivariate Cox proportional hazard regression model was also used. Results: A total of 370 patients were treated during the study period (202 in stage II and 168 in stage III). Adjuvant chemotherapy was administered to 22 and 70% of patients in stage II and III respectively. The median follow-up period was 4.6 years. The 5-year survival rate for stage II patients was 79% and there was no benefit observed with adjuvant chemotherapy. For stage III patients, the 5-year survival rate was 81% for patients who received adjuvant chemotherapy, compared to 56% for those who did not receive chemotherapy (hazard ratio (HR): 0.29; 95% confidence interval (CI): 0.15-0.56). The benefit of chemotherapy was found to persist after adjustment for other prognostic variables (HR: 0.47; 95% CI: 0.23-0.94). Conclusions: Patients with colon cancer in stage III who received adjuvant chemotherapy had a better overall survival.
dc.fechaingreso.objetodigital2024-05-29
dc.format.extent7 páginas
dc.fuente.origenWOS
dc.identifier.doi10.4067/S0034-98872016000200001
dc.identifier.eissn0717-6163
dc.identifier.issn0034-9887
dc.identifier.pubmedidMEDLINE:27092667
dc.identifier.urihttps://doi.org/10.4067/S0034-98872016000200001
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/75803
dc.identifier.wosidWOS:000371975700001
dc.information.autorucMedicina; Leal J;S/I;218729
dc.information.autorucMedicina; Padilla O;S/I;102063
dc.information.autorucMedicina; Palma S;S/I;1005531
dc.information.autorucMedicina; Zuniga A;S/I;99112
dc.information.autorucMedicina;Bellolio F ;S/I;9713
dc.information.autorucMedicina;Mondaca S;S/I;190152
dc.information.autorucMedicina;Nervi B;S/I;604
dc.information.autorucBachillerato;Villalon C;S/I;121146
dc.issue.numero2
dc.language.isoes
dc.nota.accesoContenido completo
dc.pagina.final151
dc.pagina.inicio145
dc.publisherSOC MEDICA SANTIAGO
dc.revistaREVISTA MEDICA DE CHILE
dc.rightsacceso abierto
dc.subjectAntineoplastic combined chemotherapy protocols
dc.subjectChemotherapy, adjuvant
dc.subjectColonic neoplasms
dc.subjectFluorouracil
dc.subjectTUMOR MICROSATELLITE-INSTABILITY
dc.subjectADVANCED COLORECTAL-CANCER
dc.subjectLOW-DOSE LEUCOVORIN
dc.subjectSTAGE-II
dc.subjectFOLINIC ACID
dc.subjectFLUOROURACIL
dc.subjectTHERAPY
dc.subjectSURVIVAL
dc.subjectTRIAL
dc.subjectOXALIPLATIN
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleBenefit of adjuvant 5-fluorouracil based chemotherapy for colon cancer: a retrospective cohort study
dc.typeartículo
dc.volumen144
sipa.codpersvinculados218729
sipa.codpersvinculados102063
sipa.codpersvinculados1005531
sipa.codpersvinculados99112
sipa.codpersvinculados9713
sipa.codpersvinculados190152
sipa.codpersvinculados604
sipa.codpersvinculados121146
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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