<i>In vivo</i> Activation of <i>Wnt</i> Signaling Pathway Enhances Cognitive Function of Adult Mice and Reverses Cognitive Deficits in an Alzheimer's Disease Model

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dc.contributor.authorVargas, Jessica Y.
dc.contributor.authorFuenzalida, Marco
dc.contributor.authorInestrosa, Nibaldo C.
dc.date.accessioned2025-01-23T21:47:40Z
dc.date.available2025-01-23T21:47:40Z
dc.date.issued2014
dc.description.abstractThe role of the Wnt signaling pathway during synaptic development has been well established. In the adult brain, different components of Wnt signaling are expressed, but little is known about its role in mature synapses. Emerging in vitro studies have implicated Wnt signaling in synaptic plasticity. Furthermore, activation of Wnt signaling has shown to protect against amyloid-beta-induced synaptic impairment. The present study provides the first evidence that in vivo activation of Wnt signaling improves episodic memory, increases excitatory synaptic transmission, and enhances long-term potentiation in adult wild-type mice. Moreover, the activation of Wnt signaling also rescues memory loss and improves synaptic dysfunction in APP/PS1-transgenic mice that model the amyloid pathology of Alzheimer's diseases. These findings indicate that Wnt signaling modulates cognitive function in the adult brain and could be a novel promising target for Alzheimer's disease therapy.
dc.fuente.origenWOS
dc.identifier.doi10.1523/JNEUROSCI.0862-13.2014
dc.identifier.eissn1529-2401
dc.identifier.issn0270-6474
dc.identifier.urihttps://doi.org/10.1523/JNEUROSCI.0862-13.2014
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/101745
dc.identifier.wosidWOS:000331455200017
dc.issue.numero6
dc.language.isoen
dc.pagina.final2202
dc.pagina.inicio2191
dc.revistaJournal of neuroscience
dc.rightsacceso restringido
dc.subjectAlzheimer's disease
dc.subjectAPP/PS1 mice
dc.subjectcognitive function
dc.subjectmemory
dc.subjectsynaptic plasticity
dc.subjectWnt signaling
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.title<i>In vivo</i> Activation of <i>Wnt</i> Signaling Pathway Enhances Cognitive Function of Adult Mice and Reverses Cognitive Deficits in an Alzheimer's Disease Model
dc.typeartículo
dc.volumen34
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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