Cardiovascular risk factors in vegetarians: Normalization of hyperhomocysteinemia with vitamin B-12 and reduction of platelet aggregation with n-3 fatty acids

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dc.contributor.authorMezzano, D
dc.contributor.authorKosiel, K
dc.contributor.authorMartinez, C
dc.contributor.authorCuevas, A
dc.contributor.authorPanes, O
dc.contributor.authorAranda, E
dc.contributor.authorStrobel, P
dc.contributor.authorPerez, DD
dc.contributor.authorPereira, J
dc.contributor.authorRozowski, J
dc.contributor.authorLeighton, F
dc.date.accessioned2024-01-10T12:37:53Z
dc.date.available2024-01-10T12:37:53Z
dc.date.issued2000
dc.description.abstractHyperhomocysteinemia in association with vitamin B-12 deficiency, and increased platelet aggregation, probably due to dietary lack of n-3 fatty acids, constitute cardiovascular risk factors frequently observed in vegetarians. We tested if administration of vitamin B-12 normalizes the concentration of total plasma homocysteine, and if intake of eicosapentaenoic (20:5n-3) and docosahexaenoic (22:6n-3) fatty acids modulates platelet function in a population of lactoovovegetarians. One week after a single intramuscular injection of cyanocobalamin (10000 mug) in 18 individuals, serum vitamin B-12 increased from 149+/-63 pg/mL to 532+/-204 pg/mL (p<0.0001) and total tHcy dropped from 12.4+/-4.7 to 7.9+/-3.1 <mu>mol/L (p<0.0001). Ten of fourteen of these vegetarians completed an 8-week supplementation with 700 mg/day of each eicosapentaenoic and docosahexaenoic acids. Increased incorporation of these fatty acids into plasma lipids was observed in all of them, together with a significant reduction in maximum percentage or slope of platelet aggregation with all the agonists tested (ADP, epinephrin, collagen, arachidonic acid). No significant change in bleeding time was observed after n-3 fatty acid trial. Supplementation with vitamin B-12 and n-3 fatty acids corrects hyperhomocysteinemia and reduces platelet reactivity to agonists in vegetarians. Whether this supplementation improves the already reduced cardiovascular morbidity and mortality associated with vegetarian diet has yet to be demonstrated. (C) 2000 Elsevier Science Ltd. All rights reserved.
dc.fechaingreso.objetodigital16-04-2024
dc.format.extent8 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1016/S0049-3848(00)00313-3
dc.identifier.issn0049-3848
dc.identifier.pubmedidMEDLINE:11108902
dc.identifier.urihttps://doi.org/10.1016/S0049-3848(00)00313-3
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/76945
dc.identifier.wosidWOS:000165582400006
dc.information.autorucMedicina;Aranda E;S/I;102381
dc.information.autorucMedicina;Cuevas A;S/I;79629
dc.information.autorucCiencias Biológicas;Leighton F;S/I;98261
dc.information.autorucMedicina;Mezzano D;S/I;99455
dc.information.autorucMedicina;Pereira J;S/I;99371
dc.information.autorucMedicina;Rozowski J;S/I;98948
dc.issue.numero3
dc.language.isoen
dc.nota.accesoContenido parcial
dc.pagina.final160
dc.pagina.inicio153
dc.publisherPERGAMON-ELSEVIER SCIENCE LTD
dc.revistaTHROMBOSIS RESEARCH
dc.rightsacceso restringido
dc.subjectvegetarians
dc.subjectvitamin B-12 deficiency
dc.subjecthyperhomocysteinemia
dc.subjectn-3 fatty acids
dc.subjectplatelet aggregation
dc.subjectCORONARY HEART-DISEASE
dc.subjectCOD-LIVER OIL
dc.subjectDOCOSAHEXAENOIC ACID
dc.subjectCOBALAMIN DEFICIENCY
dc.subjectPLASMA HOMOCYSTEINE
dc.subjectBLEEDING-TIME
dc.subjectEICOSAPENTAENOIC ACID
dc.subjectFISH CONSUMPTION
dc.subjectSERUM-LIPIDS
dc.subjectDIET
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleCardiovascular risk factors in vegetarians: Normalization of hyperhomocysteinemia with vitamin B-12 and reduction of platelet aggregation with n-3 fatty acids
dc.typeartículo
dc.volumen100
sipa.codpersvinculados102381
sipa.codpersvinculados79629
sipa.codpersvinculados98261
sipa.codpersvinculados99455
sipa.codpersvinculados99371
sipa.codpersvinculados98948
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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