Contribution of Dysregulated DNA Methylation to Autoimmunity

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dc.catalogadorjlo
dc.contributor.authorFunes, Samanta C.
dc.contributor.authorFernández Fierro, Ayleen
dc.contributor.authorRebolledo Zelada, Diego
dc.contributor.authorMackern Oberti, Juan P.
dc.contributor.authorKalergis, Alexis M.
dc.date.accessioned2024-01-29T17:48:30Z
dc.date.available2024-01-29T17:48:30Z
dc.date.issued2021
dc.description.abstractEpigenetic mechanisms, such as DNA methylation, histone modifications, and non-coding RNAs are known regulators of gene expression and genomic stability in cell growth, development, and differentiation. Because epigenetic mechanisms can regulate several immune system elements, epigenetic alterations have been found in several autoimmune diseases. The purpose of this review is to discuss the epigenetic modifications, mainly DNA methylation, involved in autoimmune diseases in which T cells play a significant role. For example, Rheumatoid Arthritis and Systemic Lupus Erythematosus display differential gene methylation, mostly hypomethylated 5′-C-phosphate-G-3′ (CpG) sites that may associate with disease activity. However, a clear association between DNA methylation, gene expression, and disease pathogenesis must be demonstrated. A better understanding of the impact of epigenetic modifications on the onset of autoimmunity will contribute to the design of novel therapeutic approaches for these diseases.
dc.fechaingreso.objetodigital2024-04-11
dc.fuente.origenORCID-ene24
dc.identifier.doi10.3390/ijms222111892
dc.identifier.issn1422-0067
dc.identifier.urihttps://www.mdpi.com/1422-0067/22/21/11892
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/81023
dc.information.autorucFacultad de Ciencias Biológicas; Fernández Fierro, Ayleen Lorena; S/I; 1126909
dc.information.autorucFacultad de Ciencias Biológicas; Rebolledo Zelada, Diego Maximiliano Andrés; S/I; 222100
dc.information.autorucEscuela de Medicina; Kalergis Parra, Alexis Mikes; 0000-0001-7622-5263; 90610
dc.issue.numero21
dc.language.isoen
dc.nota.accesoContenido completo
dc.pagina.final19
dc.pagina.inicio1
dc.revistaInternational Journal of Molecular Sciences
dc.rightsacceso abierto
dc.subjectDNA methylation
dc.subjectEpigenetic
dc.subjectSystemic autoimmunity
dc.subjectRheumatoid arthritis
dc.subjectCpG
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.titleContribution of Dysregulated DNA Methylation to Autoimmunity
dc.typeartículo
dc.volumen22
sipa.codpersvinculados1126909
sipa.codpersvinculados222100
sipa.codpersvinculados90610
sipa.trazabilidadORCID;2024-01-15
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