Synthesis and Biological Screening of Novel Indolalkyl Arenes Targeting the Serotonine Transporter

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dc.contributor.authorOjeda-Gomez, Claudia
dc.contributor.authorPessoa-Mahana, Hernan
dc.contributor.authorIturriaga-Vasquez, Patricio
dc.contributor.authorDavid Pessoa-Mahana, Carlos
dc.contributor.authorRecabarren-Gajardo, Gonzalo
dc.contributor.authorMendez-Rojas, Claudio
dc.date.accessioned2025-01-23T21:47:04Z
dc.date.available2025-01-23T21:47:04Z
dc.date.issued2014
dc.description.abstractA series of functionalized indolylalkylarenes 3-16(a and b) were synthesized and their affinities for the serotonin transporter were investigated in vitro. Compounds 3-12(a and b) were obtained by nucleophilic substitution of 3-(1H-indol-3-yl)propyl-4-methylbenzenesulfonates 2(a and b) with a series of azaheterocycles. Compounds 14-16(a and b) were prepared in a two-step sequence by reaction of 3-(1H-indol-3-yl)-2-methylpropanal with substituted 1,2-phenylenediamines. Compounds 3b, 4b, and 5b showed good binding affinities (K-i=33.0, 48.0, and 17nM, respectively). The other synthesized compounds showed moderate or no affinity in the binding studies.
dc.description.funderFONDECYT
dc.fuente.origenWOS
dc.identifier.doi10.1002/ardp.201300321
dc.identifier.eissn1521-4184
dc.identifier.issn0365-6233
dc.identifier.urihttps://doi.org/10.1002/ardp.201300321
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/101734
dc.identifier.wosidWOS:000332331800003
dc.issue.numero3
dc.language.isoen
dc.pagina.final184
dc.pagina.inicio174
dc.revistaArchiv der pharmazie
dc.rightsacceso restringido
dc.subjectBenzimidazole
dc.subjectIndole
dc.subjectSerotonine transporter
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleSynthesis and Biological Screening of Novel Indolalkyl Arenes Targeting the Serotonine Transporter
dc.typeartículo
dc.volumen347
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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