Metabolic flexibility to lipid during exercise is not associated with metabolic health outcomes in individuals without obesity

Simple item page
dc.article.number28642
dc.catalogadorpva
dc.contributor.authorFernández Verdejo, Rodrigo
dc.contributor.authorGutierrez-Pino, Juan
dc.contributor.authorHayes Ortiz, Thomas Emilio
dc.contributor.authorZbinden Foncea, Hermann
dc.contributor.authorCabello Verrugio, Claudio Alejandro
dc.contributor.authorValero-Breton, Mayalen
dc.contributor.authorTunon-Suarez, Mauro
dc.contributor.authorVargas-Foitzick, Ronald
dc.contributor.authorGalgani Fuentes, José
dc.date.accessioned2025-04-15T20:29:02Z
dc.date.available2025-04-15T20:29:02Z
dc.date.issued2024
dc.description.abstractA low metabolic flexibility to lipid (MetF-lip) in skeletal muscle may promote ectopic lipid accumulation, thus inducing metabolic disturbances. We aimed to determine the association between MetF-lip in skeletal muscle and metabolic health outcomes in individuals without obesity. We also explored the association between MetF-lip and the inflammatory signaling pathway in skeletal muscle. This was a cross-sectional study in 17 individuals aged (median [IQR]) 55.4 [48.6, 58.5] years, with a BMI of 24.4 [22.6, 26.0] kg/m(2). MetF-lip was assessed as the increase in relative lipid oxidation during a single exercise session (similar to 50% VO(2)max, 2 hours), quantified as the drop in whole-body respiratory exchange ratio (Delta RER = RER at 2 hours - maximum RER attained). HOMA-IR, metabolic syndrome z-score, fat percentage, trunk-to-appendicular fat, and VO(2)max were included as metabolic health outcomes. The abundance of proteins of the inflammatory pathway was analyzed in resting muscle. Acute exercise progressively increased relative lipid oxidation (Delta RER = -0.04 [-0.08, -0.02]). MetF-lip was not associated with any metabolic health outcome but correlated inversely with p-p38(Thr180/Tyr182) in muscle. A low MetF-lip in skeletal muscle does not seem a major determinant of metabolic disturbances but associates with a partial activation of the inflammatory signaling in individuals without obesity.
dc.description.funderNational Institute of Diabetes and Digestive And Kidney Diseases
dc.description.funderAgencia Nacional de Investigación y Desarrollo
dc.description.funderFONDECYT
dc.description.funderUNAB
dc.description.funderNational Institutes of Health
dc.fechaingreso.objetodigital2025-04-15
dc.format.extent12 páginas
dc.fuente.origenORCID
dc.identifier.doi10.1038/s41598-024-79092-w
dc.identifier.issn2045-2322
dc.identifier.scopusidSCOPUS_ID:85209377957
dc.identifier.urihttps://doi.org/10.1038/s41598-024-79092-w
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/103314
dc.identifier.wosidWOS:001360393700031
dc.information.autorucDepartamento de Ciencias de la Salud; Fernández Verdejo, Rodrigo; 0000-0002-5948-2281; 1071485
dc.information.autorucEscuela de Medicina; Hayes Ortiz, Thomas Emilio; S/I; 1124115
dc.information.autorucFacultad de Ciencias Biológicas; Cabello Verrugio, Claudio Alejandro; S/I; 134336
dc.information.autorucDepartamento de Ciencias de la Salud; Galgani Fuentes, José; 0000-0001-9793-8561; 1011272
dc.issue.numero1
dc.language.isoen
dc.nota.accesocontenido completo
dc.publisherNature Research
dc.revistaScientific Reports
dc.rightsacceso abierto
dc.rights.licenseAttribution-NonCommercial-NoDerivatives 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectMitogen-activated protein kinases
dc.subjectCardiorespiratory Fitness
dc.subjectBody composition
dc.subjectInsulin resistance
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.subject.ods03 Good health and well-being
dc.subject.odspa03 Salud y bienestar
dc.titleMetabolic flexibility to lipid during exercise is not associated with metabolic health outcomes in individuals without obesity
dc.typeartículo
dc.volumen14
sipa.codpersvinculados1071485
sipa.codpersvinculados1124115
sipa.codpersvinculados134336
sipa.codpersvinculados1011272
sipa.trazabilidadORCID;2025-03-03
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
s41598-024-79092-w.pdf
Size:
2.12 MB
Format:
Adobe Portable Document Format
Description:
Download
Collections
Artículos de revistas