Routine screening for SARS CoV-2 in unselected pregnant women at delivery

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dc.contributor.authorDiaz-Corvillon, Pilar
dc.contributor.authorMonckeberg, Max
dc.contributor.authorBarros, Antonia
dc.contributor.authorIllanes, Sebastian E.
dc.contributor.authorSoldati, Arturo
dc.contributor.authorNien, Jyh-Kae
dc.contributor.authorSchepeler, Manuel
dc.contributor.authorCaradeux, Javier
dc.date.accessioned2025-01-23T19:48:21Z
dc.date.available2025-01-23T19:48:21Z
dc.date.issued2020
dc.description.abstractBackground
dc.description.abstractSouth America has become the epicenter of coronavirus pandemic. It seems that asymptomatic population may contribute importantly to the spread of the disease. Transmission from asymptomatic pregnant patients' needs to be characterized in larger population cohorts and symptom assessment needs to be standardized.
dc.description.abstractObjective
dc.description.abstractTo assess the prevalence of SARS CoV-2 infection in an unselected obstetrical population and to describe their presentation and clinical evolution.
dc.description.abstractMethods
dc.description.abstractA cross-sectional study was designed. Medical records of pregnant women admitted at the Obstetrics & Gynecology department of Clinica Davila for labor & delivery, between April 27(th)and June 7(th), 2020 were reviewed. All patients were screened with RT-PCR for SARS CoV-2 at admission. After delivery, positive cases were inquired by the researchers for clinical symptoms presented before admission and clinical evolution. All neonates born from mothers with confirmed SARS CoV-2 were isolated and tested for SARS CoV-2 infection.
dc.description.abstractResults
dc.description.abstractA total of 586 patients were tested for SARS CoV-2 during the study period. Outcomes were obtained from 583 patients which were included in the study. Thirty-seven pregnant women had a positive test for SARS CoV-2 at admission. Cumulative prevalence of confirmed SARS CoV-2 infection was 6.35% (37/583) [CI 95%: 4.63-8.65]. From confirmed cases, 43.2% (16/37) were asymptomatic. From symptomatic patients 85.7% (18/21) had mild symptoms and evolved without complications and 14.3% (3/21) presented severe symptoms requiring admission to intensive care unit. Only 5.4% (2/37) of the neonates born to mothers with a positive test at admission had a positive RT-PCR for SARS CoV-2.
dc.description.abstractConclusion
dc.description.abstractIn our study nearly half of pregnant patients with SARS CoV-2 were asymptomatic at the time of delivery. Universal screening, in endemic areas, is necessary for adequate patient isolation, prompt neonatal testing and targeted follow-up.
dc.fuente.origenWOS
dc.identifier.doi10.1371/journal.pone.0239887
dc.identifier.issn1932-6203
dc.identifier.urihttps://doi.org/10.1371/journal.pone.0239887
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/100440
dc.identifier.wosidWOS:000576632300011
dc.issue.numero9
dc.language.isoen
dc.revistaPlos one
dc.rightsacceso restringido
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleRoutine screening for SARS CoV-2 in unselected pregnant women at delivery
dc.typeartículo
dc.volumen15
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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