Organization of the Catecholaminergic System in the Short-Lived Fish <i>Nothobranchius furzeri</i>

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dc.contributor.authorBorgonovo, Janina
dc.contributor.authorAhumada-Galleguillos, Patricio
dc.contributor.authorOnate-Ponce, Alejandro
dc.contributor.authorAllende-Castro, Camilo
dc.contributor.authorHenny, Pablo
dc.contributor.authorConcha, Miguel L.
dc.date.accessioned2025-01-20T22:07:24Z
dc.date.available2025-01-20T22:07:24Z
dc.date.issued2021
dc.description.abstractThe catecholaminergic system has received much attention based on its regulatory role in a wide range of brain functions and its relevance in aging and neurodegenerative diseases. In the present study, we analyzed the neuroanatomical distribution of catecholaminergic neurons based on tyrosine hydroxylase (TH) immunoreactivity in the brain of adult Nothobranchius furzeri. In the telencephalon, numerous TH+ neurons were observed in the olfactory bulbs and the ventral telencephalic area, arranged as strips extending through the rostrocaudal axis. We found the largest TH+ groups in the diencephalon at the preoptic region level, the ventral thalamus, the pretectal region, the posterior tuberculum, and the caudal hypothalamus. In the dorsal mesencephalic tegmentum, we identified a particular catecholaminergic group. The rostral rhombencephalon housed TH+ cells in the locus coeruleus and the medulla oblongata, distributing in a region dorsal to the inferior reticular formation, the vagal lobe, and the area postrema. Finally, scattered TH+ neurons were present in the ventral spinal cord and the retina. From a comparative perspective, the overall organization of catecholaminergic neurons is consistent with the general pattern reported for other teleosts. However, N. furzeri shows some particular features, including the presence of catecholaminergic cells in the midbrain. This work provides a detailed neuroanatomical map of the catecholaminergic system of N. furzeri, a powerful aging model, also contributing to the phylogenetic understanding of one of the most ancient neurochemical systems.</p>
dc.fuente.origenWOS
dc.identifier.doi10.3389/fnana.2021.728720
dc.identifier.issn1662-5129
dc.identifier.urihttps://doi.org/10.3389/fnana.2021.728720
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/94238
dc.identifier.wosidWOS:000703781300001
dc.language.isoen
dc.revistaFrontiers in neuroanatomy
dc.rightsacceso restringido
dc.subjecttyrosine hydroxylase
dc.subjectcatecholaminergic system
dc.subjectaging
dc.subjectannual killifish
dc.subjectNothobranchius furzeri
dc.subjectteleosts
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleOrganization of the Catecholaminergic System in the Short-Lived Fish <i>Nothobranchius furzeri</i>
dc.typeartículo
dc.volumen15
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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