Early-life nutrition interacts with developmental genes to shape the brain and sleep behavior in Drosophila melanogaster

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dc.contributor.authorOlivares, Gonzalo H.
dc.contributor.authorNunez-Villegas, Franco
dc.contributor.authorCandia, Noemi
dc.contributor.authorOrostica, Karen
dc.contributor.authorGonzalez-Ramirez, M. Constanza
dc.contributor.authorVega-Macaya, Franco
dc.contributor.authorZuniga, Nolberto
dc.contributor.authorMolina, Cristian
dc.contributor.authorOliva, Carlos
dc.contributor.authorMackay, Trudy F. C.
dc.contributor.authorVerdugo, Ricardo A.
dc.contributor.authorOlguin, Patricio
dc.date.accessioned2025-01-20T20:17:20Z
dc.date.available2025-01-20T20:17:20Z
dc.date.issued2023
dc.description.abstractThe mechanisms by which the genotype interacts with nutrition during development to contribute to the variation of complex behaviors and brain morphology of adults are not well understood. Here we use the Drosophila Genetic Reference Panel to identify genes and pathways underlying these interactions in sleep behavior and mushroom body morphology. We show that early-life nutritional restriction effects on sleep behavior and brain morphology depends on the genotype. We mapped genes associated with sleep sensitivity to early-life nutrition, which were enriched for protein-protein interactions responsible for translation, endocytosis regulation, ubiquitination, lipid metabolism, and neural development. By manipulating the expression of candidate genes in the mushroom bodies (MBs) and all neurons, we confirm that genes regulating neural development, translation and insulin signaling contribute to the variable response of sleep and brain morphology to early-life nutrition. We show that the interaction between differential expression of candidate genes with nutritional restriction in early life resides in the MBs or other neurons and that these effects are sex-specific. Natural variations in genes that control the systemic response to nutrition and brain development and function interact with early-life nutrition in different types of neurons to contribute to the variation of brain morphology and adult sleep behavior.
dc.fuente.origenWOS
dc.identifier.doi10.1093/sleep/zsad016
dc.identifier.eissn1550-9109
dc.identifier.issn0161-8105
dc.identifier.urihttps://doi.org/10.1093/sleep/zsad016
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/92391
dc.identifier.wosidWOS:000940742800001
dc.issue.numero4
dc.language.isoen
dc.revistaSleep
dc.rightsacceso restringido
dc.subjectprenatal nutrition
dc.subjectsleep
dc.subjectmushroom bodies
dc.subjectgenome-wide association
dc.subjectbehavioral genetics
dc.subjectgenetic networks
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleEarly-life nutrition interacts with developmental genes to shape the brain and sleep behavior in Drosophila melanogaster
dc.typeartículo
dc.volumen46
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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