Cold-adaptation of a methacrylamide gelatin towards the expansion of the biomaterial toolbox for specialized functionalities in tissue engineering

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dc.catalogadorpva
dc.contributor.authorZaupa, A.
dc.contributor.authorByres, N.
dc.contributor.authorDal Zovo, C.
dc.contributor.authorAcevedo, C.A.
dc.contributor.authorAngelopoulos, I.
dc.contributor.authorTerrazaa, C.
dc.contributor.authorNestle, N.
dc.contributor.authorAbarzua-Illanes, P.N.
dc.contributor.authorQuero, F.
dc.contributor.authorZacconi, Flavia C. M.
dc.contributor.authorDiaz-Calderon, P.
dc.contributor.authorOlguin, Y.
dc.contributor.authorAkentjew, T.L.
dc.contributor.authorWilkens, C.A.
dc.contributor.authorPadilla, C.
dc.contributor.authorPino-Lagos, K.
dc.contributor.authorBlaker, U.J.
dc.contributor.authorKhoury, M.
dc.contributor.authorEnrione, J.
dc.contributor.authorAcevedo, J.P.
dc.date.accessioned2023-08-24T17:26:55Z
dc.date.available2023-08-24T17:26:55Z
dc.date.issued2019
dc.description.abstractTissue regeneration is witnessing a significant surge in advanced medicine. It requires the interaction of scaffolds with different cell types for efficient tissue formation post-implantation. The presence of tissue subtypes in more complex organs demands the co-existence of different biomaterials showing different hydrolysis rate for specialized cell-dependent remodeling. To expand the available toolbox of biomaterials with sufficient mechanical strength and variable rate of enzymatic degradation, a cold-adapted methacrylamide gelatin was developed from salmon skin. Compared with mammalian methacrylamide gelatin (GeIMA), hydrogels derived from salmon GelMA displayed similar mechanical properties than the former. Nevertheless, salmon gelatin and salmon Ge1MA-derived hydrogels presented characteristics common of cold-adaptation, such as reduced activation energy for collagenase, increased enzymatic hydrolysis turnover of hydrogels, increased interconnected poly-peptides molecular mobility and lower physical gelation capability. These properties resulted in increased cell remodeling rate in vitro and in vivo, proving the potential and biological tolerance of this mechanically adequate cold-adapted biomaterial as alternative scaffold subtypes with improved cell invasion and tissue fusion capacity.
dc.fechaingreso.objetodigital2023-08-24
dc.format.extent18 páginas
dc.fuente.origenConveris
dc.identifier.doi10.1016/j.msec.2019.04.020
dc.identifier.issn0928-4931
dc.identifier.pubmedidMEDLINE:31147009
dc.identifier.urihttps://doi.org/10.1016/j.msec.2019.04.020
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/74484
dc.identifier.wosidWOS:000472241700037
dc.information.autorucEscuela de Química; Zacconi, Flavia C. M.; 0000-0002-3676-0453; 1011127
dc.language.isoen
dc.nota.accesoContenido completo
dc.pagina.final390
dc.pagina.inicio373
dc.revistaMaterials Science and Engineering: Ces_ES
dc.rightsacceso abierto
dc.subjectCold-adaptedes_ES
dc.subjectGelatines_ES
dc.subjectSalmones_ES
dc.subjectMethacrylamidees_ES
dc.subjectTissue engineeringes_ES
dc.subject.ddc620
dc.subject.deweyIngenieríaes_ES
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleCold-adaptation of a methacrylamide gelatin towards the expansion of the biomaterial toolbox for specialized functionalities in tissue engineeringes_ES
dc.typeartículo
dc.volumen102
sipa.codpersvinculados1011127
sipa.indexISI-2019-2020
sipa.trazabilidadConveris;20-07-2021
sipa.trazabilidadORCID;2023-08-21
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