Effect of 0.25 ppm Ozone exposure on. pulmonary damage induced by bleomycin

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dc.contributor.authorOyarzun, M
dc.contributor.authorDussaubat, N
dc.contributor.authorGonzalez, S
dc.date.accessioned2024-01-10T13:47:49Z
dc.date.available2024-01-10T13:47:49Z
dc.date.issued2005
dc.description.abstractTo study the effect of ozone in a chronically damaged lung. we used a bleomycin (BLM) induced pulmonary fibrosis model. Both endotracheal instillation of BLM and O-3 exposure both produce lung inflammation and fibrosis. Oxidative stress would be a common mechanism of damage for both BLM and O-3. Our aim was to assess lung injury induced by 5 and 60 days of intermittent exposure to 0.25 ppm O-3 in rats with bleomycin-induced pulmonary fibrosis. Thirty-day-old Sprague Dawley rats were endotracheally instilled with BLM (IU/100 g body weight) and, 30 days later, exposed to 0.25 ppm O-3 (0.25 ppm 4 h per day, 5 days a week). Histopatology controls were instilled with saline and breathing room air. Histopathological evaluation of lungs was done 5 and 60 days after O-3 exposure. BLM-induced lung damage did not change after 60 days of days of O-3 exposure. Five days of O-3 exposure increased the mean score of BLM-induced pulmonary suggesting that a short-term exposure to O-3 in a previously damaged lung might be a risk factor for developing further lung injury.
dc.fechaingreso.objetodigital2024-06-19
dc.format.extent6 páginas
dc.fuente.origenWOS
dc.identifier.issn0716-9760
dc.identifier.pubmedidMEDLINE:16579517
dc.identifier.urihttp://dx.doi.org/10.4067/S0716-97602005000400007
dc.identifier.wosidWOS:000236190300007
dc.information.autorucMedicina;González S;S/I;99856
dc.issue.numero4
dc.language.isoen
dc.nota.accesoContenido completo
dc.pagina.final358
dc.pagina.inicio353
dc.publisherSOCIEDAD BIOLGIA CHILE
dc.revistaBIOLOGICAL RESEARCH
dc.rightsacceso abierto
dc.subjectbleomycin
dc.subjecthistopathology
dc.subjectlung damage
dc.subjectozone exposure
dc.subjectINDUCED LUNG INJURY
dc.subjectFIBROSIS
dc.subjectMICE
dc.subjectINFLAMMATION
dc.subjectPOLLUTION
dc.subject.ods03 Good Health and Well-being
dc.subject.ods11 Sustainable Cities and Communities
dc.subject.odspa03 Salud y bienestar
dc.subject.odspa11 Ciudades y comunidades sostenibles
dc.titleEffect of 0.25 ppm Ozone exposure on. pulmonary damage induced by bleomycin
dc.typeartículo
dc.volumen38
sipa.codpersvinculados99856
sipa.indexWOS
sipa.indexScielo
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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