Selective depletion of Vβ2+CD8+ T cells in peripheral blood from rheumatic heart disease patients

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dc.contributor.authorCarrión, F
dc.contributor.authorFernandez, M
dc.contributor.authorIruretagoyena, M
dc.contributor.authorAndrade, LEC
dc.contributor.authorOdete-Hilário, M
dc.contributor.authorFigueroa, F
dc.date.accessioned2025-01-21T01:09:40Z
dc.date.available2025-01-21T01:09:40Z
dc.date.issued2003
dc.description.abstractAcute rheumatic fever (ARF) and its chronic valvular sequelae are the delayed consequence of a pharyngeal infection with group A Streptococcus (GAS). Several GAS proteins have been shown to be superantigens, raising the possibility that the expansion or deletion of T cells expressing specific Vbeta regions might play a role in the pathogenesis of ARF or chronic rheumatic heart disease (RHD). We therefore analyzed by four-color flow cytometry, the V repertoire on CD3, CD4 and CD8 T cells from four ARF patients, 10 RHD patients and also nine healthy controls. A selective depletion of Vbeta2+ T cells was found only in the CD8 subset of chronic RHD patients. This is of interest since a number of GAS superantigens exert their effects on Vbeta2+ cells and because only CD8+ T cells from ARF and RHD patients undergo anergy in response to GAS superantigens. Our results suggests that an ongoing immune process is present in RHD patients and that CD8+ T cells may have an important immunoregulatory role in the pathogenesis of the disease. (C) 2003 Elsevier Science Ltd. All rights reserved.
dc.fuente.origenWOS
dc.identifier.doi10.1016/S0896-8411(03)00002-7
dc.identifier.eissn1095-9157
dc.identifier.issn0896-8411
dc.identifier.urihttps://doi.org/10.1016/S0896-8411(03)00002-7
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/96608
dc.identifier.wosidWOS:000181562500009
dc.issue.numero2
dc.language.isoen
dc.pagina.final190
dc.pagina.inicio183
dc.revistaJournal of autoimmunity
dc.rightsacceso restringido
dc.subjectrheumatic heart disease
dc.subjectrheumatic fever
dc.subjectsuperantigens
dc.subjectT cells
dc.subjectT-cell receptor
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleSelective depletion of Vβ2+CD8+ T cells in peripheral blood from rheumatic heart disease patients
dc.typeartículo
dc.volumen20
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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