Studies on quinones. Part 38: Synthesis and leishmanicidal activity of sesquiterpene 1,4-quinones

Simple item page
dc.contributor.authorValderrama, JA
dc.contributor.authorBenites, J
dc.contributor.authorCortes, M
dc.contributor.authorPessoa Mahana, H
dc.contributor.authorPrina, E
dc.contributor.authorFournet, A
dc.date.accessioned2024-01-10T14:21:45Z
dc.date.available2024-01-10T14:21:45Z
dc.date.issued2003
dc.description.abstractThe reaction of (+)-euryfuran 1 with several benzo-, naphtho- and benzo[b]thiophene-1,4-quinones in acetic acid yields the corresponding euryfuryl-1.4-quinones 3, 5, 7, 8, 10, 12, and 14. The structure of compounds 7, 8, 12, and 14 was assigned through 2D NMR H-1-C-13 HMBC experiments. The influence of the acidity of the solvent upon the reactivity and regioselectivity of the quinones to the oxidative coupling reaction, is discussed. The in vitro activity of the euryfurylquinones and their corresponding precursors against Leishmania amazonensis is described. (C) 2003 Elsevier Ltd. All rights reserved.
dc.fechaingreso.objetodigital20-03-2024
dc.format.extent6 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1016/j.bmc.2003.08.011
dc.identifier.eissn1464-3391
dc.identifier.issn0968-0896
dc.identifier.pubmedidMEDLINE:14556786
dc.identifier.urihttps://doi.org/10.1016/j.bmc.2003.08.011
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/79771
dc.identifier.wosidWOS:000186134200003
dc.information.autorucQuímica;Cortés M;S/I;98607
dc.information.autorucQuímica;Valderrama J;S/I;98772
dc.issue.numero22
dc.language.isoen
dc.nota.accesocontenido parcial
dc.pagina.final4718
dc.pagina.inicio4713
dc.publisherPERGAMON-ELSEVIER SCIENCE LTD
dc.revistaBIOORGANIC & MEDICINAL CHEMISTRY
dc.rightsacceso restringido
dc.subjectANTIPROTOZOAL ACTIVITY
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleStudies on quinones. Part 38: Synthesis and leishmanicidal activity of sesquiterpene 1,4-quinones
dc.typeartículo
dc.volumen11
sipa.codpersvinculados98607
sipa.codpersvinculados98772
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
2024-03-20. Studies on Quinones. Part 38 - Synthesis and Leishmanicidal Activity of Sesquiterpene 1,4-Quinones.pdf
Size:
2.45 KB
Format:
Adobe Portable Document Format
Description:
Download
Collections
Artículos de revistas