Lipophorin receptors regulate mushroom body development and complex behaviors in Drosophila

Simple item page
dc.article.number198
dc.contributor.authorRojo Cortés, Francisca Rayén
dc.contributor.authorFuenzalida-Uribe, Nicolás
dc.contributor.authorTapia Valladares, Victoria
dc.contributor.authorRoa, Candy B.
dc.contributor.authorHidalgo Sotelo, Sergio Ignacio
dc.contributor.authorGonzález Ramírez, María Constanza
dc.contributor.authorOliva Olave, Carlos Andrés
dc.contributor.authorCampusano Astorga, Jorge Mauricio
dc.contributor.authorMarzolo Canales, María Paz
dc.date.accessioned2022-09-23T14:57:16Z
dc.date.available2022-09-23T14:57:16Z
dc.date.issued2022
dc.date.updated2022-09-11T00:03:14Z
dc.description.abstractBackground: Drosophila melanogaster lipophorin receptors (LpRs), LpR1 and LpR2, are members of the LDLR family known to mediate lipid uptake in a range of organisms from Drosophila to humans. The vertebrate orthologs of LpRs, ApoER2 and VLDL-R, function as receptors of a glycoprotein involved in development of the central nervous system, Reelin, which is not present in flies. ApoER2 and VLDL-R are associated with the development and function of the hippocampus and cerebral cortex, important association areas in the mammalian brain, as well as with neurodevelopmental and neurodegenerative disorders linked to those regions. It is currently unknown whether LpRs play similar roles in the Drosophila brain. Results: We report that LpR-deficient flies exhibit impaired olfactory memory and sleep patterns, which seem to reflect anatomical defects found in a critical brain association area, the mushroom bodies (MB). Moreover, cultured MB neurons respond to mammalian Reelin by increasing the complexity of their neurite arborization. This effect depends on LpRs and Dab, the Drosophila ortholog of the Reelin signaling adaptor protein Dab1. In vitro, two of the long isoforms of LpRs allow the internalization of Reelin, suggesting that Drosophila LpRs interact with human Reelin to induce downstream cellular events. Conclusions: These findings demonstrate that LpRs contribute to MB development and function, supporting the existence of a LpR-dependent signaling in Drosophila, and advance our understanding of the molecular factors functioning in neural systems to generate complex behaviors in this model. Our results further emphasize the importance of Drosophila as a model to investigate the alterations in specific genes contributing to neural disorders.
dc.format.extent22 páginas
dc.fuente.origenAutoarchivo
dc.identifier.citationBMC Biology. 2022 Sep 07;20(1):198
dc.identifier.doi10.1186/s12915-022-01393-1
dc.identifier.urihttps://doi.org/10.1186/s12915-022-01393-1
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/64871
dc.identifier.wosidWOS:000850801800001
dc.information.autorucFacultad de ciencias biológicas ; Rojo Cortés, Francisca Rayén ; 0000-0003-2332-8423 ; 221031
dc.information.autorucFacultad de ciencias biológicas ; Tapia Valladares, Victoria ; S/I ; 1046302
dc.information.autorucFacultad de ciencias biológicas ; Roa, Candy B. ; S/I ; 1049275
dc.information.autorucFacultad de ciencias biológicas ; Hidalgo Sotelo, Sergio Ignacio ; S/I ; 205482
dc.information.autorucFacultad de ciencias biológicas ; González Ramírez, María Constanza ; S/I ; 185020
dc.information.autorucFacultad de ciencias biológicas ; Oliva Olave, Carlos Andrés ; 0000-0002-9551-149X ; 121075
dc.information.autorucFacultad de ciencias biológicas ; Campusano Astorga, Jorge Mauricio ; 0000-0001-5254-8340 ; 3965
dc.information.autorucFacultad de ciencias biológicas ; Marzolo Canales, María Paz ; 0000-0002-2328-2464 ; 72595
dc.language.isoen
dc.nota.accesoContenido completo
dc.pagina.final22
dc.pagina.inicio1
dc.revistaBMC Biology
dc.rightsacceso abierto
dc.rights.holderThe Author(s)
dc.subjectLipophorin receptores_ES
dc.subjectLipoprotein receptores_ES
dc.subjectMushroom bodieses_ES
dc.subjectReelines_ES
dc.subjectDabes_ES
dc.subjectNeuronal developmentes_ES
dc.subjectNeurite morphogenesises_ES
dc.subject.ddc570
dc.subject.deweyBiologíaes_ES
dc.subject.ods03 Good health and well-being
dc.subject.odspa03 Salud y bienestar
dc.titleLipophorin receptors regulate mushroom body development and complex behaviors in Drosophilaes_ES
dc.typeartículo
dc.volumen20
sipa.codpersvinculados221031
sipa.codpersvinculados1046302
sipa.codpersvinculados1049275
sipa.codpersvinculados205482
sipa.codpersvinculados185020
sipa.codpersvinculados121075
sipa.codpersvinculados3965
sipa.codpersvinculados72595
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
12915_2022_Article_1393.pdf
Size:
5.71 MB
Format:
Adobe Portable Document Format
Description:
Download
License bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
license.txt
Size:
0 B
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
Artículos de revistas