Hemostatic disorder of uremia: The platelet defect, main determinant of the prolonged bleeding time, is correlated with indices of activation of coagulation and fibrinolysis

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dc.contributor.authorMezzano, D
dc.contributor.authorTagle, R
dc.contributor.authorPanes, O
dc.contributor.authorPerez, M
dc.contributor.authorDowney, P
dc.contributor.authorMunoz, B
dc.contributor.authorAranda, E
dc.contributor.authorBarja, P
dc.contributor.authorThambo, S
dc.contributor.authorGonzalez, F
dc.contributor.authorMezzano, S
dc.contributor.authorPereira, J
dc.date.accessioned2024-01-10T13:13:26Z
dc.date.available2024-01-10T13:13:26Z
dc.date.issued1996
dc.description.abstractSeveral parameters of primary hemostasis and markers of activation of coagulation and fibrinolysis were measured in 38 patients with severe (creatinine clearance <20 ml/min) chronic renal failure (CRF) without dialysis and diseases or drugs affecting hemostasis. Bleeding time (BT) was prolonged in 25/48 patients, and was correlated with age of patients, severity of renal failure, hematocrit, impairment in platelet aggregation-secretion and decrease in platelet ATP content. Defects in von Willebrand factor played no role in the prolongation of the BT. Multivariate analysis showed that only platelet dysfunction and severity of renal disease were independent predictors of the BT in uremia. The platelet functional disorder was significantly correlated with a reduction in platelet ATP and ADP.
dc.description.abstractHigh levels of plasma thrombin-antithrombin complexes (TAT), prothrombin fragment F-1+2, fibrinogen and factor VIIc were observed in patients with CRF, as described in prethrombotic states. Plasmin-antiplasmin complexes (PAP), fibrinogen and fibrin degradation products (FgDP, FnDP) were significantly increased, and the activity of plasminogen activator Inhibitor (PAI-I) was slightly reduced, denoting an activation of fibrinolysis.
dc.description.abstractA negative correlation was found between platelet levels of ATP and ADP with plasma TAT, F-1+2 and PAP. Furthermore, plasma PAI-1 activity was negatively correlated with the BT and was lower in patients with prolonged BT as compared with controls and patients with normal BT. These links between primary hemostasis and activation of coagulation and fibrinolysis suggest that increased intravascular generation of thrombin and/or plasmin is an important mediator of the defects in primary hemostasis, prolongation of the BT and, probably, bleeding in CRF.
dc.fechaingreso.objetodigital2024-06-25
dc.format.extent10 páginas
dc.fuente.origenWOS
dc.identifier.eissn2567-689X
dc.identifier.issn0340-6245
dc.identifier.pubmedidMEDLINE:8883263
dc.identifier.urihttps://doi.org/10.1055/s-0038-1650576
dc.identifier.wosidWOS:A1996VG80600004
dc.information.autorucMedicina;Mezzano D;S/I;99455
dc.information.autorucMedicina;Pereira J;S/I;99371
dc.issue.numero3
dc.language.isoen
dc.nota.accesoContenido parcial
dc.pagina.final321
dc.pagina.inicio312
dc.publisherGEORG THIEME VERLAG KG
dc.revistaTHROMBOSIS AND HAEMOSTASIS
dc.rightsacceso restringido
dc.subjectCHRONIC-RENAL-FAILURE
dc.subjectGLYCOPROTEIN-IIB-IIIA
dc.subjectRED-CELL TRANSFUSIONS
dc.subjectVONWILLEBRAND-FACTOR
dc.subjectENDOTHELIAL-CELLS
dc.subjectPLASMINOGEN-ACTIVATOR
dc.subjectANTITHROMBIN-III
dc.subjectMAINTENANCE HEMODIALYSIS
dc.subjectADENOSINE-DIPHOSPHATE
dc.subjectFIBRINOGEN RECEPTORS
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleHemostatic disorder of uremia: The platelet defect, main determinant of the prolonged bleeding time, is correlated with indices of activation of coagulation and fibrinolysis
dc.typeartículo
dc.volumen76
sipa.codpersvinculados99455
sipa.codpersvinculados99371
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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