CETP expression enhances liver HDL-cholesteryl ester uptake but does not alter VLDL and biliary lipid secretion

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dc.contributor.authorHarada, Lila M.
dc.contributor.authorAmigo, Ludwig
dc.contributor.authorCazita, Patricia M.
dc.contributor.authorSalerno, Alessandro G.
dc.contributor.authorRigotti, Attilio A.
dc.contributor.authorQuintao, Eder C. R.
dc.contributor.authorOliveira, Helena C. F.
dc.date.accessioned2024-01-10T13:11:37Z
dc.date.available2024-01-10T13:11:37Z
dc.date.issued2007
dc.description.abstractThe aim of this work was to study how CETP expression affects whole body cholesterol homeostasis. Thus, tissue uptake and plasma removal rates of labeled HDL-cholesteryl ester (CE), VLDL secretion rates, and biliary lipid secretion and fecal bile acid content were compared between human CETP transgenic (Tg) and non-transgenic (nTg) mice fed with a standard diet. CETPTg mice exhibited increased HDL-CE plasma fractional catabolic rate and uptake by the liver, adrenalls, adipose tissue and spleen. HDL fractions from both CETP Tg and from nTg mice were removed faster from the plasma of CETP expressing than from nTg mice, suggesting a direct role of CETP in accelerating tissue CE uptake. However, neither hepatic output of VLDL cholesterol and triglycerides nor biliary lipid and fecal bile acid excretion were changed in CETP Tg compared to nTg mice. CETP Tg mice also showed enhanced hepatic cholesterol content. Steady state cholesterol homeostasis was probably preserved through the downregulation of hepatic HMG-CoA reductase and LDL receptor expression. In conclusion, although CETP expression facilitates cholesteryl ester tissue uptake, it does not alter biliary lipid and fecal bile acid excretion, the mandatory final step of the reverse cholesterol transport. (c) 2006 Elsevier Ireland Ltd. All rights reserved.
dc.fechaingreso.objetodigital20-03-2024
dc.format.extent6 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1016/j.atherosclerosis.2006.05.036
dc.identifier.eissn1879-1484
dc.identifier.issn0021-9150
dc.identifier.pubmedidMEDLINE:16806230
dc.identifier.urihttps://doi.org/10.1016/j.atherosclerosis.2006.05.036
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/78071
dc.identifier.wosidWOS:000245730100012
dc.information.autorucMedicina;Rigotti A;S/I;68489
dc.issue.numero2
dc.language.isoen
dc.nota.accesocontenido parcial
dc.pagina.final318
dc.pagina.inicio313
dc.publisherELSEVIER IRELAND LTD
dc.revistaATHEROSCLEROSIS
dc.rightsacceso restringido
dc.subjectcholesterol metabolism
dc.subjectbile acid metabolism
dc.subjectreverse cholesterol transport
dc.subjecthepatic HDL uptake
dc.subjectVLDL metabolism
dc.subjectCETP transgenic mice
dc.subjectDENSITY-LIPOPROTEIN-CHOLESTEROL
dc.subject7-ALPHA-HYDROXYLASE GENE CYP7A1
dc.subjectMEDIATES SELECTIVE UPTAKE
dc.subjectTRANSFER PROTEIN GENE
dc.subjectTRANSGENIC MICE
dc.subjectDIETARY-CHOLESTEROL
dc.subjectDOWN-REGULATION
dc.subjectX RECEPTOR
dc.subjectIN-VIVO
dc.subjectTRANSPORT
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleCETP expression enhances liver HDL-cholesteryl ester uptake but does not alter VLDL and biliary lipid secretion
dc.typeartículo
dc.volumen191
sipa.codpersvinculados68489
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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