Differentially Expressed Genes and Signaling Pathways Potentially Involved in Primary Resistance to Chemo-Immunotherapy in Advanced-Stage Gastric Cancer Patients

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dc.article.number1
dc.catalogadorjwg
dc.contributor.authorPinto, Mauricio P.
dc.contributor.authorBravo, María Loreto
dc.contributor.authorCórdova Delgado, Miguel
dc.contributor.authorHill, Charlotte N.
dc.contributor.authorMuñoz Medel, Matías
dc.contributor.authorRetamal, Ignacio N.
dc.contributor.authorFernández, M. Fernanda
dc.contributor.authorSánchez, Carolina
dc.contributor.authorSáez, Mauricio A.
dc.contributor.authorMorales Pison, Sebastián
dc.contributor.authorGarcía Bloj, Benjamín
dc.contributor.authorGarrido, Marcelo
dc.contributor.authorLatapiat, Verónica
dc.contributor.authorMartín, Alberto J.M.
dc.contributor.authorFernández Ramírez, Ricardo
dc.contributor.authorOwen Gareth Ivor
dc.date.accessioned2024-01-26T14:36:28Z
dc.date.available2024-01-26T14:36:28Z
dc.date.issued2023
dc.description.abstractRecently, the combination of chemotherapy plus nivolumab (chemo-immunotherapy) has become the standard of care for advanced-stage gastric cancer (GC) patients. However, despite its efficacy, up to 40% of patients do not respond to these treatments. Our study sought to identify variations in gene expression associated with primary resistance to chemo-immunotherapy. Diagnostic endoscopic biopsies were retrospectively obtained from advanced GC patients previously categorized as responders (R) or non-responders (NR). Thirty-four tumor biopsies (R: n = 16, NR: n = 18) were analyzed by 3? massive analysis of cDNA ends (3?MACE). We found >30 differentially expressed genes between R and NRs. Subsequent pathway enrichment analyses demonstrated that angiogenesis and the Wnt-?-catenin signaling pathway were enriched in NRs. Concomitantly, we performed next generation sequencing (NGS) analyses in a subset of four NR patients that confirmed alterations in genes that belonged to the Wnt/?-catenin and the phosphoinositide 3-kinase (PI3K) pathways. We speculate that angiogenesis, the Wnt, and the PI3K pathways might offer actionable targets. We also discuss therapeutic alternatives for chemo-immunotherapy-resistant advanced-stage GC patients.
dc.description.funderFinanciamiento Basal para Centros Científicos y Tecnológicos de Excelencia de ANID
dc.description.funderFondecyt Iniciacion
dc.description.funderBristol Myers Squibb
dc.description.funderFONDECYT
dc.description.funderMIII
dc.fechaingreso.objetodigital2024-06-05
dc.identifier.doi10.3390/ijms24010001
dc.identifier.eissn14220067
dc.identifier.issn14220067 16616596
dc.identifier.pubmedid36613445
dc.identifier.scopusidSCOPUS_ID:85145978931
dc.identifier.urihttp://www.mdpi.com/journal/ijms
dc.identifier.urihttps://doi.org/10.3390/ijms24010001
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/80979
dc.information.autorucFacultad de Ciencias Biológicas; Owen Gareth Ivor; 0000-0003-3807-6054; 1000459
dc.issue.numero1
dc.language.isoen
dc.nota.accesoContenido completo
dc.publisherMDPI
dc.relation.ispartofInternational Journal of Molecular Sciences
dc.revistaInternational Journal of Molecular Sciences
dc.rightsacceso abierto
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.subject.ods03 Good health and well-being
dc.subject.odspa03 Salud y bienestar
dc.titleDifferentially Expressed Genes and Signaling Pathways Potentially Involved in Primary Resistance to Chemo-Immunotherapy in Advanced-Stage Gastric Cancer Patients
dc.typeartículo
dc.volumen24
sipa.codpersvinculados1000459
sipa.trazabilidadORCID;2024-01-15
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