Diagnostic MRI Score to Differentiate Susac Syndrome from Primary Angiitis of the Central Nervous System and Multiple Sclerosis

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dc.contributor.authorMarrodan, Mariano
dc.contributor.authorCalandri, Ismael L.
dc.contributor.authorBocancea, Diana I.
dc.contributor.authorYsrraelit, Maria C.
dc.contributor.authorFigueroa, Enrique Gomez
dc.contributor.authorPaez, Montserrat Masso
dc.contributor.authorFlores, Jose D. J.
dc.contributor.authorRojas, Juan I.
dc.contributor.authorCiampi, Ethel
dc.contributor.authorIoli, Pablo
dc.contributor.authorZanga, Gisela
dc.contributor.authorArdohain, Carolina
dc.contributor.authorFracaro, Maria E.
dc.contributor.authorAmaya, Mariela
dc.contributor.authorTkachuk, Veronica
dc.contributor.authorFernandez, Victoria C.
dc.contributor.authorJose, Gustavo
dc.contributor.authorSilva, Emanuel
dc.contributor.authorLuetic, Geraldine
dc.contributor.authorContentti, Edgar Carnero
dc.contributor.authorKohler, Eduardo
dc.contributor.authorCassara, Fatima Pagani
dc.contributor.authorMoran, Dolores
dc.contributor.authorSeimandi, Carla
dc.contributor.authorPaviolo, Juan P.
dc.contributor.authorD'elio, Brenda
dc.contributor.authorDa Prat, Gustavo
dc.contributor.authorGatto, Emilia
dc.contributor.authorCristiano, Edgardo
dc.contributor.authorLereis, Virginia Pujol
dc.contributor.authorAmeriso, Sebastian F.
dc.contributor.authorFiol, Marcela P.
dc.contributor.authorCorreale, Jorge
dc.date.accessioned2025-01-20T16:11:49Z
dc.date.available2025-01-20T16:11:49Z
dc.date.issued2024
dc.description.abstractObjective: Susac syndrome (SuS), multiple sclerosis (MS), and primary angiitis of the central nervous system (PACNS) present diagnostic challenges due to overlapping clinical features. We aimed to enhance diagnostic precision by developing the SPAMS (SuS, PACNS, MS) score, a practical radiological tool. Methods: This multicenter study included 99 patients (43 SuS, 37 MS, 19 PACNS) from South American countries. Relevant MRI features were identified through an elastic-net model determined key variables. Results: The SPAMS score assigned 2 points for snowball lesions, 1 point for spokes-like lesions, or if there are more than 4 lesions in the corpus callosum, corpus callosum involvement, or cerebellar involvement. It subtracted 1 point if gadolinium-enhancing lesions or 4 points if Dawson's fingers are present. Bootstrapping validated the optimal cutoff at 2 points, exhibiting a diagnostic performance of area under the curve = 0.931, sensitivity = 88%, specificity = 89%, positive predictive value = 88%, negative predictive value = 89%, and accuracy = 88%. Interpretation: When specific MRI findings coexisted, the SPAMS score differentiated SuS from MS and PACNS. Access to MRI and standard protocol sequences makes it a valuable tool for timely diagnosis and treatment, potentially preventing disability progression and severe clinical outcomes.
dc.fuente.origenWOS
dc.identifier.doi10.1002/ana.27043
dc.identifier.eissn1531-8249
dc.identifier.issn0364-5134
dc.identifier.urihttps://doi.org/10.1002/ana.27043
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/90295
dc.identifier.wosidWOS:001280671700001
dc.issue.numero5
dc.language.isoen
dc.pagina.final854
dc.pagina.inicio846
dc.revistaAnnals of neurology
dc.rightsacceso restringido
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleDiagnostic MRI Score to Differentiate Susac Syndrome from Primary Angiitis of the Central Nervous System and Multiple Sclerosis
dc.typeartículo
dc.volumen96
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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