ADAMTS4-specific MR probe to assess aortic aneurysms in vivo using synthetic peptide libraries

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dc.contributor.authorKaufmann, Jan O.
dc.contributor.authorBrangsch, Julia
dc.contributor.authorKader, Avan
dc.contributor.authorSaatz, Jessica
dc.contributor.authorMangarova, Dilyana B.
dc.contributor.authorZacharias, Martin
dc.contributor.authorKempf, Wolfgang E.
dc.contributor.authorSchwaar, Timm
dc.contributor.authorPonader, Marco
dc.contributor.authorAdams, Lisa C.
dc.contributor.authorMoeckel, Jana
dc.contributor.authorBotnar, Rene M.
dc.contributor.authorTaupitz, Matthias
dc.contributor.authorMaegdefessel, Lars
dc.contributor.authorTraub, Heike
dc.contributor.authorHamm, Bernd
dc.contributor.authorWeller, Michael G.
dc.contributor.authorMakowski, Marcus R.
dc.date.accessioned2025-01-20T21:06:55Z
dc.date.available2025-01-20T21:06:55Z
dc.date.issued2022
dc.description.abstractNew biomarkers are required to improve the assessment of aortic wall integrity and risk of rupture. Here the authors report the development of an imaging probe for ADAMTS4, which they test in an abdominal aortic aneurysm mouse model and show in vivo prediction of aneurysm and rupture.
dc.description.abstractThe incidence of abdominal aortic aneurysms (AAAs) has substantially increased during the last 20 years and their rupture remains the third most common cause of sudden death in the cardiovascular field after myocardial infarction and stroke. The only established clinical parameter to assess AAAs is based on the aneurysm size. Novel biomarkers are needed to improve the assessment of the risk of rupture. ADAMTS4 (A Disintegrin And Metalloproteinase with ThromboSpondin motifs 4) is a strongly upregulated proteoglycan cleaving enzyme in the unstable course of AAAs. In the screening of a one-bead-one-compound library against ADAMTS4, a low-molecular-weight cyclic peptide is discovered with favorable properties for in vivo molecular magnetic resonance imaging applications. After identification and characterization, it's potential is evaluated in an AAA mouse model. The ADAMTS4-specific probe enables the in vivo imaging-based prediction of aneurysm expansion and rupture.
dc.fuente.origenWOS
dc.identifier.doi10.1038/s41467-022-30464-8
dc.identifier.eissn2041-1723
dc.identifier.urihttps://doi.org/10.1038/s41467-022-30464-8
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/93380
dc.identifier.wosidWOS:000802699200001
dc.issue.numero1
dc.language.isoen
dc.revistaNature communications
dc.rightsacceso restringido
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleADAMTS4-specific MR probe to assess aortic aneurysms in vivo using synthetic peptide libraries
dc.typeartículo
dc.volumen13
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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