Association between the brain injury location and its volume with the severity profile of language impairment measured with the ScreeLing in Chilean adults after stroke: a pilot study

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dc.catalogadorpva
dc.contributor.advisorMendez Orellana, Carolina
dc.contributor.authorUrrutia Goldsack, Francisca Pilar
dc.contributor.otherPontificia Universidad Católica de Chile. Escuela de Medicina
dc.date.accessioned2024-09-04T21:24:57Z
dc.date.available2024-09-04T21:24:57Z
dc.date.issued2024
dc.date.updated2024-09-04T16:22:21Z
dc.descriptionTesis (Magíster en Investigación en Ciencias de la Salud)--Pontificia Universidad Católica de Chile, 2024
dc.description.abstractIntroduction: Post-stroke aphasia is a high-prevalence disorder that impacts an individual's quality of life, environment, and health care systems. Thanks to novel neuroimaging techniques, new cortical language processing models have emerged; however, characterizing the neuronal organization associated with a linguistic task and domain has proven to be surprisingly challenging. This study aims to explore associations between the brain injury location and extension with the severity profile of language impairment measured with the Chilean version of the ScreeLing in post-stroke adults.Methods: This is an analytical, observational, cross-sectional study. We recruited 144 post-stroke adults within the first week after stroke. Neuroimaging and language performance data were collected. Our dependent variable was the ScreeLing score, while the brain injury location and volume were the independent variables. Linear regression models were performed in RStudio using a significance level of p < 0.05.Results: Among the patients, ScreeLing diagnosed 56 with aphasia and 60 without linguistic disorders, while 28 could not be included in the analysis. In the aphasic group, linear regressions revealed an association between the left temporal lesion and phonological performance; subcortical lesions correlated with lower phonological and syntactic scores. Poorer performance in the overall ScreeLing was associated with injuries in the left temporal lobe and subcortical regions. No association was found between the ScreeLing performance and the extension of the lesion.Conclusions: This study corroborated associations described in modern language processing models. Our future efforts will focus on precise location of the lesion and expand the sample size evaluated with MRI.
dc.fechaingreso.objetodigital2024-09-04
dc.format.extent18 páginas sin numerar
dc.fuente.origenAutoarchivo
dc.identifier.doi10.7764/tesisUC/MED/87795
dc.identifier.urihttps://doi.org/10.7764/tesisUC/MED/87795
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/87795
dc.information.autorucEscuela de Medicina; Mendez Orellana, Carolina; 0000-0001-5217-9725; 1015155
dc.information.autorucEscuela de Medicina; Urrutia Goldsack, Francisca Pilar; S/I; 251528
dc.language.isoen
dc.nota.accesocontenido completo
dc.rightsacceso abierto
dc.rights.licenseAtribución-SinDerivadas 4.0 Internacional (CC BY-ND 4.0)
dc.rights.urihttps://creativecommons.org/licenses/by-nd/4.0/deed.es
dc.subjectAphasia
dc.subjectStroke
dc.subjectMRI
dc.subjectPhonology
dc.subjectSemantics
dc.subjectSyntax
dc.subjectLanguage processing
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.subject.ods03 Good health and well-being
dc.subject.odspa03 Salud y bienestar
dc.titleAssociation between the brain injury location and its volume with the severity profile of language impairment measured with the ScreeLing in Chilean adults after stroke: a pilot study
dc.typetesis de maestría
sipa.codpersvinculados1015155
sipa.codpersvinculados251528
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