Tibial subchondral trabecular bone micromechanical and microarchitectural properties are affected by alignment and osteoarthritis stage

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dc.contributor.authorRenault, Jean-Baptiste
dc.contributor.authorCarmona, Maximiliano
dc.contributor.authorTzioupis, Chris
dc.contributor.authorOllivier, Matthieu
dc.contributor.authorArgenson, Jean-Noel
dc.contributor.authorParratte, Sebastien
dc.contributor.authorChabrand, Patrick
dc.date.accessioned2025-01-23T19:48:55Z
dc.date.available2025-01-23T19:48:55Z
dc.date.issued2020
dc.description.abstractAt advanced knee osteoarthritis (OA) stages subchondral trabecular bone (STB) is altered. Lower limb alignment plays a role in OA progression and modify the macroscopic loading of the medial and lateral condyles of the tibial plateau. How the properties of the STB relate to alignment and OA stage is not well defined. OA stage (KL scores 2-4) and alignment (HKA from 17 degrees Varus to 8 degrees Valgus) of 30 patients were measured and their tibial plateau were collected after total knee arthroplasty. STB tissue elastic modulus, bone volume fraction (BV/TV) and trabecula thickness (Tb.Th) were evaluated with nanoindentation and mu CT scans (8.1 mu m voxel-size) of medial and lateral samples of each plateau. HKA and KL scores were statistically significantly associated with STB elastic modulus, BV/TV and Tb.Th. Medial to lateral BV/TV ratio correlated with HKA angle (R = -0.53, p = 0.016), revealing a higher ratio for varus than valgus subjects. STB properties showed lower values for KL stage 4 patients. Tissue elastic modulus ratios and BV.TV ratios were strongly correlated (R = 0.81, p < 0.001). Results showed that both micromechanical and microarchitectural properties of STB are affected by macroscopic loading at late stage knee OA. For the first time, a strong association between tissue stiffness and quantity of OA STB was demonstrated.
dc.description.funderAix Marseille University
dc.fuente.origenWOS
dc.identifier.doi10.1038/s41598-020-60464-x
dc.identifier.issn2045-2322
dc.identifier.urihttps://doi.org/10.1038/s41598-020-60464-x
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/100468
dc.identifier.wosidWOS:000563271000006
dc.issue.numero1
dc.language.isoen
dc.revistaScientific reports
dc.rightsacceso restringido
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleTibial subchondral trabecular bone micromechanical and microarchitectural properties are affected by alignment and osteoarthritis stage
dc.typeartículo
dc.volumen10
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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