Kinin Receptors B1 and B2 Mediate Breast Cancer Cell Migration and Invasion by Activating the FAK-Src Axis

Simple item page
dc.contributor.authorGonzalez-Turen, Felipe
dc.contributor.authorLobos-Gonzalez, Lorena
dc.contributor.authorRiquelme-Herrera, Alexander
dc.contributor.authorIbacache, Andres
dc.contributor.authorMeza Ulloa, Luis
dc.contributor.authorDroguett, Alexandra
dc.contributor.authorAlveal, Camila
dc.contributor.authorCarrillo, Bastian
dc.contributor.authorGutierrez, Javiera
dc.contributor.authorEhrenfeld, Pamela
dc.contributor.authorCardenas-Oyarzo, Areli
dc.date.accessioned2025-01-20T16:04:35Z
dc.date.available2025-01-20T16:04:35Z
dc.date.issued2024
dc.description.abstractKinin receptors B1 and B2 are involved in migration and invasion in gastric, glioma, and cervical cancer cells, among others. However, the role of kinin receptors in breast cancer cells has been poorly studied. We aimed to reveal the impact of B1 and B2 receptors on migration and invasion in breast cancer cells and demonstrate their capacity to modulate in vivo tumor growth. MDA-MB-231, MCF-7, and T47D cells treated with Lys-des[Arg9]bradykinin (LDBK) or bradykinin (BK) were used to evaluate migration and invasion. Des-[Arg9]-Leu8-BK and HOE-140 were used as antagonists for the B1 and B2 receptors. MDA-MB-231 cells incubated or not with antagonists were subcutaneously inoculated in BALBc NOD/SCID mice to evaluate tumor growth. LDBK and BK treatment significantly increased migration and invasion in breast cancer cells, effects that were negated when antagonists were used. The use of antagonists in vivo inhibited tumor growth. Moreover, the migration and invasion induced by kinins in breast cancer cells were inhibited when focal adhesion kinase (FAK) and Src inhibitors were used. The novelty revealed in our work is that B1 and B2 receptors activated by LDBK and BK induce migration and invasion in breast cancer cells via a mechanism that involves the FAK-Src signaling pathway, and the antagonism of both receptors in vivo impairs breast tumor growth.
dc.fuente.origenWOS
dc.identifier.doi10.3390/ijms252111709
dc.identifier.eissn1422-0067
dc.identifier.issn1661-6596
dc.identifier.urihttps://doi.org/10.3390/ijms252111709
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/89809
dc.identifier.wosidWOS:001351417100001
dc.issue.numero21
dc.language.isoen
dc.revistaInternational journal of molecular sciences
dc.rightsacceso restringido
dc.subjectkinin receptors
dc.subjectB1 receptor
dc.subjectB2 receptor
dc.subjectmigration
dc.subjectinvasion
dc.subjectbreast cancer
dc.subjectFAK
dc.subjectSrc
dc.titleKinin Receptors B1 and B2 Mediate Breast Cancer Cell Migration and Invasion by Activating the FAK-Src Axis
dc.typeartículo
dc.volumen25
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
Files
Collections
Artículos de revistas