Association between salt intake and gastric atrophy by <i>Helicobacter pylori</i> infection: first results from the Epidemiological Investigation of Gastric Malignancy (ENIGMA)

Simple item page
dc.contributor.authorKnaze, Viktoria
dc.contributor.authorFreisling, Heinz
dc.contributor.authorCook, Paz
dc.contributor.authorHeise, Katy
dc.contributor.authorAcevedo, Johanna
dc.contributor.authorCikutovic, Marcos
dc.contributor.authorWagner, Karl-Heinz
dc.contributor.authorMarculescu, Rodrig
dc.contributor.authorFerreccio, Catterina
dc.contributor.authorHerrero, Rolando
dc.contributor.authorPark, Jin Young
dc.date.accessioned2025-01-20T20:16:23Z
dc.date.available2025-01-20T20:16:23Z
dc.date.issued2023
dc.description.abstractPurposeGastric atrophy (GA), usually linked to chronic infection with Helicobacter pylori (H. pylori), may over time evolve into gastric malignancy. Besides H. pylori, high salt intake may play a role in GA development. This study evaluates cross sectionally the association between salt intake and GA in Chilean adults.MethodsPopulation-based samples were recruited from two sites, Antofagasta and Valdivia, partaking in the Epidemiological Investigation of Gastric Malignancies. At recruitment, participants answered questionnaires and provided biospecimens. Salt intake (g/day) was estimated from casual spot urine samples using the Tanaka equation. GA was determined by serum pepsinogen levels. Only participants >= 40 to 70 years of age were considered in this analysis, n = 565. For the association between salt intake (as sex-specific quartiles) and GA, odds ratios (ORs) and the corresponding 95% confidence intervals (CI) were estimated through multivariable logistic regression.ResultsIn women, the multivariable-adjusted OR for GA comparing quartile 4 of the estimated salt intake (12.8 g/day) to quartile 1 (6.6 g/day) was 1.18 (95% CI 0.52-2.68, P-trend = 0.87). The corresponding OR in men was 0.49 (95% CI 0.19-1.27, P-trend = 0.17) with salt intakes of 12.8 g/day and 7.1 g/day for quartiles 4 and 1, respectively.ConclusionThere was little evidence for an association between salt intake estimated from spot urine and GA risk in our cross-sectional analysis of middle aged and older adults in Chile. Reverse causation bias cannot be ruled out and the sample size was limited to provide more precise estimates.
dc.fuente.origenWOS
dc.identifier.doi10.1007/s00394-023-03132-w
dc.identifier.eissn1436-6215
dc.identifier.issn1436-6207
dc.identifier.urihttps://doi.org/10.1007/s00394-023-03132-w
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/92326
dc.identifier.wosidWOS:000951934200001
dc.issue.numero5
dc.language.isoen
dc.pagina.final2138
dc.pagina.inicio2129
dc.revistaEuropean journal of nutrition
dc.rightsacceso restringido
dc.subjectAtrophic gastritis
dc.subjectStomach cancer
dc.subjectSodium excretion
dc.subjectH
dc.subjectpylori
dc.subjectTanaka equation
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleAssociation between salt intake and gastric atrophy by <i>Helicobacter pylori</i> infection: first results from the Epidemiological Investigation of Gastric Malignancy (ENIGMA)
dc.typeartículo
dc.volumen62
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
Files
Collections
Artículos de revistas