The effects of progesterone on immune cellular function at the maternal-fetal interface and in maternal circulation

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dc.contributor.authorMotomura, Kenichiro
dc.contributor.authorMiller, Derek
dc.contributor.authorGalaz, Jose
dc.contributor.authorLiu, Tzu Ning
dc.contributor.authorRomero, Roberto
dc.contributor.authorGomez-Lopez, Nardhy
dc.date.accessioned2025-01-20T20:17:51Z
dc.date.available2025-01-20T20:17:51Z
dc.date.issued2023
dc.description.abstractProgesterone is a sex steroid hormone that plays a critical role in the establishment and maintenance of pregnancy. This hormone drives numerous maternal physiological adaptations to ensure the continuation of pregnancy and to facilitate fetal growth, including broad and potent modulation of the maternal immune system to promote maternal-fetal tolerance. In this brief review, we provide an overview of the immunomodulatory functions of progesterone in the decidua, placenta, myometrium, and maternal circulation during pregnancy. Specifically, we summarize current evidence of the regulated functions of innate and adaptive immune cells induced by progesterone and its downstream effector molecules in these compartments, including observations in human pregnancy and in animal models. Our review highlights the gaps in knowledge of interactions between progesterone and maternal cellular immunity that may direct future research.
dc.fuente.origenWOS
dc.identifier.doi10.1016/j.jsbmb.2023.106254
dc.identifier.eissn1879-1220
dc.identifier.issn0960-0760
dc.identifier.urihttps://doi.org/10.1016/j.jsbmb.2023.106254
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/92425
dc.identifier.wosidWOS:000930505400001
dc.language.isoen
dc.revistaJournal of steroid biochemistry and molecular biology
dc.rightsacceso restringido
dc.subjectDecidua
dc.subjectDendritic cell
dc.subjectMacrophage
dc.subjectNeutrophil
dc.subjectNK cell
dc.subjectPregnancy
dc.subjectT cell
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleThe effects of progesterone on immune cellular function at the maternal-fetal interface and in maternal circulation
dc.typeartículo
dc.volumen229
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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