Neural tube defects prevalence does not increase after modification of the folic acid fortification program in Chile

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dc.catalogadordfo
dc.contributor.authorPardo, Rosa
dc.contributor.authorVilca, Marcela
dc.contributor.authorVillarroel del Pino, Luis A.
dc.contributor.authorDavalji, Tahera
dc.contributor.authorObrycki, John F.
dc.contributor.authorMazumdar, Maitreyi
dc.contributor.authorÁvila, Claudia
dc.contributor.authorMellado Sagredo, Cecilia
dc.date.accessioned2024-01-22T16:22:21Z
dc.date.available2024-01-22T16:22:21Z
dc.date.issued2022
dc.description.abstractBackground:In 2000, Chile’s Ministry of Health mandated fortification ofwheat flour with folic acid at a concentration of 2.2 mg/kg to prevent neuraltube defects (NTDs), resulting in a 50% reduction in NTD prevalence. Con-cerns about possible collateral effects of high folic acid intake led, in 2009, todecrease the folic acid fortification to 1.8 mg/kg of flour. Our study evaluatedthe impact of this modification on the prevalence of NTDs in Santiago.Methods:This study measured the prevalence of NTDs in live births and still-births born in Santiago. We calculated prevalence ratios (PR) and 95% confi-dence intervals (CI) between pre-folic acid fortification (1999–2000), post-folicacid fortification (2001–2009), and post-modified folic acid fortification (2010–2015) periods for all NTDs and their specific types. We used chi-square tests toanalyze proportions, and a Joinpoint regression to visualize prevalence timetrends.Results:The NTD prevalence for the period 2001–2015 was 8.9 per 10,000births, which represents a 48% reduction (PR=0.52; 95% CI=0.45–0.61;p< .001) from the pre-folic acid fortification period. During 2010–2015, theNTD prevalence was 9.5/10,000 births, which was higher, but not statisticallysignificantly different from 2001 to 2009 prevalence of 8.6/10,000 (PR=1.11;95% CI=0.96–1.30,p=.17).Conclusions:Decreasing the concentration of folic acid fortification was notassociated with a statistically significant change in the prevalence of NTDs.Mandatory folic acid fortification continues to be a safe and highly effectivepolicy to prevent NTDs. Future studies should evaluate the prevalence ofNTDs across Chile and adherence to folic acid fortification mandates
dc.fechaingreso.objetodigital2024-10-29
dc.fuente.origenORCID-ene24
dc.identifier.doi10.1002/bdr2.1994
dc.identifier.issn2472-1727
dc.identifier.urihttps://doi.org/10.1002/bdr2.1994
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/80893
dc.identifier.wosidWOS:000761250600001
dc.information.autorucEscuela de Medicina; Villarroel del Pino, Luis A.; 0000-0001-9603-937X; 77182
dc.information.autorucEscuela de Medicina; Mellado Sagredo, Cecilia; 0000-0002-6032-4651; 1002671
dc.issue.numero7
dc.language.isoen
dc.nota.accesocontenido parcial
dc.pagina.final266
dc.pagina.inicio259
dc.revistaBirth Defects Research
dc.rightsacceso restringido
dc.subjectChile
dc.subjectFolic acid
dc.subjectFortification
dc.subjectNeural tube defects
dc.subject.ddc600
dc.subject.deweyTecnologíaes_ES
dc.subject.ods03 Good health and well-being
dc.subject.odspa03 Salud y bienestar
dc.titleNeural tube defects prevalence does not increase after modification of the folic acid fortification program in Chile
dc.typeartículo
dc.volumen114
sipa.codpersvinculados77182
sipa.codpersvinculados1002671
sipa.trazabilidadWOS;18-03-2022
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