Functional consequences of SARS-CoV-2 infection in pregnant women, fetoplacental unit, and neonate

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dc.contributor.authorCarvajal, Jorge
dc.contributor.authorCasanello, Paola
dc.contributor.authorToso, Alberto
dc.contributor.authorFarias, Marcelo
dc.contributor.authorCarrasco-Negue, Karina
dc.contributor.authorAraujo, Kenny
dc.contributor.authorValero, Paola
dc.contributor.authorFuenzalida, Javiera
dc.contributor.authorSolari, Caterina
dc.contributor.authorSobrevia, Luis
dc.date.accessioned2024-01-10T14:25:57Z
dc.date.available2024-01-10T14:25:57Z
dc.date.issued2023
dc.description.abstractThe SARS-CoV-2 infection causes COVID-19 disease, characterized by acute respiratory distress syndrome, bilateral pneumonia, and organ failure. The consequences of maternal SARS-CoV-2 infection for the pregnant woman, fetus, and neonate are controversial. Thus, it is required to determine whether there is viral and non -viral vertical transmission in COVID-19. The disease caused by SARS-CoV-2 leads to functional alterations in asymptomatic and symptomatic pregnant women, the fetoplacental unit and the neonate. Several diseases of pregnancy, including COVID-19, affect the fetoplacental function, which causes in utero programming for young and adult diseases. A generalized inflammatory state and a higher risk of infection are seen in pregnant women with COVID-19. Obesity, diabetes mellitus, and hypertension may increase the vulnerability of pregnant women to infection by SARS-CoV-2. Alpha, Delta, and Omicron variants of SARS-CoV-2 show specific mutations that seem to increase the capacity of the virus to infect the pregnant woman, likely due to increasing its interaction via the virus S protein and angiotensin-converting enzyme 2 receptors. This review shows the literature addressing to what extent COVID-19 in pregnancy affects the pregnant woman, fetoplacental unit, and neonate. Prospective studies that are key in managing SARS-CoV-2 infection in pregnancy are discussed.
dc.fechaingreso.objetodigital19-04-2024
dc.fuente.origenWOS
dc.identifier.doi10.1016/j.bbadis.2022.166582
dc.identifier.eissn1879-260X
dc.identifier.issn0925-4439
dc.identifier.urihttps://doi.org/10.1016/j.bbadis.2022.166582
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/80389
dc.identifier.wosidWOS:000880192400004
dc.information.autorucFacultad de Medicina; Farias Jofre, Marcelo Enrique; S/I; 12286
dc.issue.numero1
dc.language.isoen
dc.nota.accesocontenido parcial
dc.publisherELSEVIER
dc.revistaBIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
dc.rightsacceso restringido
dc.subjectVirus
dc.subjectPregnancy
dc.subjectPlacenta
dc.subjectFetus
dc.subjectNeonate
dc.subjectCovid-19
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleFunctional consequences of SARS-CoV-2 infection in pregnant women, fetoplacental unit, and neonate
dc.typereseña
dc.volumen1869
sipa.codpersvinculados12286
sipa.indexWOS
sipa.trazabilidadCarga SIPA;09-01-2024
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