Dengue infection during pregnancy and transplacental antibody transfer in Thai mothers

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dc.contributor.authorPerret, C
dc.contributor.authorChanthavanich, P
dc.contributor.authorPengsaa, K
dc.contributor.authorLimkittikul, K
dc.contributor.authorHutajaroen, P
dc.contributor.authorBunn, JEG
dc.contributor.authorBrabin, BJ
dc.date.accessioned2024-01-10T12:04:52Z
dc.date.available2024-01-10T12:04:52Z
dc.date.issued2005
dc.description.abstractObjectives. The objectives of this study were to estimate dengue seroprevalence in a population of Thai pregnant women, Living in a highly endemic area and placental transfer of dengue antibodies.
dc.description.abstractMethods. A cross-sectional seroprevalence study of 245 pregnant women at delivery.
dc.description.abstractResults. Dengue HAI antibodies were positive in 94.7%. Maternal age was the only risk factor associated with dengue infection as older mothers (>20 years) were significantly more likely to be seropositive than younger women (p<0.0001). Cord antibody titres varied with maternal age and antibody titre, were significantly higher in babies born to younger mothers (<20 years) (p=0.01), and were significantly correlated with maternal titre. Low birthweight babies had Lower transfer ratios for DEN-2 antibody (1.06) compared to heavier babies (1.36, p=0.05). No mother or neonate had dengue IgM detected. Two women were classified as recently, but not currently infected with dengue virus and we consider it likely these were first trimester infections. As no infant became infected the fetal infection was 0%.
dc.description.abstractConclusions. Younger mothers were more likely to have been recently infected, resulting in higher antibody titres. Maternal dengue antibody transfer was proportional to maternal antibody concentration. (C) 2004 The British Infection Society. Published by Elsevier Ltd. All rights reserved.
dc.fechaingreso.objetodigital27-03-2024
dc.format.extent7 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1016/j.jinf.2004.10.003
dc.identifier.eissn1532-2742
dc.identifier.issn0163-4453
dc.identifier.pubmedidMEDLINE:16291281
dc.identifier.urihttps://doi.org/10.1016/j.jinf.2004.10.003
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/75897
dc.identifier.wosidWOS:000233650500003
dc.information.autorucMedicina;Perret C;S/I;80387
dc.issue.numero4
dc.language.isoen
dc.nota.accesocontenido parcial
dc.pagina.final293
dc.pagina.inicio287
dc.publisherW B SAUNDERS CO LTD
dc.revistaJOURNAL OF INFECTION
dc.rightsacceso restringido
dc.subjectdengue antibodies
dc.subjectpregnancy
dc.subjecttransplacental transfer
dc.subjectcongenital infection
dc.subjectHEMORRHAGIC-FEVER
dc.subjectVERTICAL TRANSMISSION
dc.subjectFC-RECEPTORS
dc.subjectEPIDEMIOLOGY
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleDengue infection during pregnancy and transplacental antibody transfer in Thai mothers
dc.typeartículo
dc.volumen51
sipa.codpersvinculados80387
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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