The Association between Fasting Glucose and Sugar Sweetened Beverages Intake Is Greater in Latin Americans with a High Polygenic Risk Score for Type 2 Diabetes Mellitus

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dc.contributor.authorLopez-Portillo, Maria Lourdes
dc.contributor.authorHuidobro, Andrea
dc.contributor.authorTobar-Calfucoy, Eduardo
dc.contributor.authorYanez, Cristian
dc.contributor.authorRetamales-Ortega, Rocio
dc.contributor.authorGarrido-Tapia, Macarena
dc.contributor.authorAcevedo, Johanna
dc.contributor.authorParedes, Fabio
dc.contributor.authorCid-Ossandon, Vicente
dc.contributor.authorFerreccio, Catterina
dc.contributor.authorVerdugo, Ricardo A.
dc.date.accessioned2025-01-20T22:00:53Z
dc.date.available2025-01-20T22:00:53Z
dc.date.issued2022
dc.description.abstractChile is one of the largest consumers of sugar-sweetened beverages (SSB) world-wide. However, it is unknown whether the effects from this highly industrialized food will mimic those reported in industrialized countries or whether they will be modified by local lifestyle or population genetics. Our goal is to evaluate the interaction effect between SSB intake and T2D susceptibility on fasting glucose. We calculated a weighted genetic risk score (GRSw) based on 16 T2D risk SNPs in 2828 non-diabetic participants of the MAUCO cohort. SSB intake was categorized in four levels using a food frequency questionnaire. Log-fasting glucose was regressed on SSB and GRSw tertiles while accounting for socio-demography, lifestyle, obesity, and Amerindian ancestry. Fasting glucose increased systematically per unit of GRSw (beta = 0.02 +/- 0.006, p = 0.00002) and by SSB intake (beta[cat4] = 0.04 +/- 0.01, p = 0.0001), showing a significant interaction, where the strongest effect was observed in the highest GRSw-tertile and in the highest SSB consumption category (beta = 0.05 +/- 0.02, p = 0.02). SNP-wise, SSB interacted with additive effects of rs7903146 (TCF7L2) (beta = 0.05 +/- 0.01, p = 0.002) and with the G/G genotype of rs10830963 (MTNRB1B) (beta = 0.19 +/- 0.05, p = 0.001). Conclusions: The association between SSB intake and fasting glucose in the Chilean population without diabetes is modified by T2D genetic susceptibility.
dc.fuente.origenWOS
dc.identifier.doi10.3390/nu14010069
dc.identifier.eissn2072-6643
dc.identifier.urihttps://doi.org/10.3390/nu14010069
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/93757
dc.identifier.wosidWOS:000748187800001
dc.issue.numero1
dc.language.isoen
dc.revistaNutrients
dc.rightsacceso restringido
dc.subjectsugar-sweetened beverages
dc.subjectfasting glucose
dc.subjectgenetic risk score
dc.subjecttype 2 diabetes mellitus
dc.subjectnutritional epidemiology
dc.subjectgenotype by environment interaction
dc.subjectLatin American ancestry
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleThe Association between Fasting Glucose and Sugar Sweetened Beverages Intake Is Greater in Latin Americans with a High Polygenic Risk Score for Type 2 Diabetes Mellitus
dc.typeartículo
dc.volumen14
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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