T2 gallbladder cancer shows substantial survival variation between continents and this is not due to histopathologic criteria or pathologic sampling differences

Simple item page
dc.contributor.authorDeSimone, Mia S.
dc.contributor.authorGoodman, Michael
dc.contributor.authorPehlivanoglu, Burcin
dc.contributor.authorMemis, Bahar
dc.contributor.authorBalci, Serdar
dc.contributor.authorRoa, Juan Carlos
dc.contributor.authorJang, Kee-Taek
dc.contributor.authorJang, Jin-Young
dc.contributor.authorHong, Seung-Mo
dc.contributor.authorLee, Kyoungbun
dc.contributor.authorKim, Haeryoung
dc.contributor.authorChoi, Hye-Jeong
dc.contributor.authorMuraki, Takashi
dc.contributor.authorAraya, Juan Carlos
dc.contributor.authorBellolio, Enrique
dc.contributor.authorSarmiento, Juan M.
dc.contributor.authorMaithel, Shishir K.
dc.contributor.authorLosada, Hector F.
dc.contributor.authorBasturk, Olca
dc.contributor.authorReid, Michelle D.
dc.contributor.authorKoshiol, Jill
dc.contributor.authorAdsay, Volkan
dc.date.accessioned2025-01-20T23:55:24Z
dc.date.available2025-01-20T23:55:24Z
dc.date.issued2021
dc.description.abstractPublished data on survival of T2 gallbladder carcinoma (GBC) from different countries show a wide range of 5-year survival rates from 30-> 70%. Recently, studies have demonstrated substantial variation between countries in terms of their approach to sampling gallbladders, and furthermore, that pathologists from different continents apply highly variable criteria in determining stage of invasion in this organ. These findings raised the question of whether these variations in pathologic evaluation could account for the vastly different survival rates of T2 GBC reported in the literature. In this study, survival of 316 GBCs from three countries (Chile n = 137, South Korea n = 105, USA n = 74), all adequately sampled (with a minimum of five tumor sections examined) and histopathologically verified as pT2 (after consensus examination by expert pathologists from three continents), was analyzed. Chilean patients had a significantly worse prognosis based on 5-year all-cause mortality (HR: 1.89, 95% CI: 1.27-2.83, p = 0.002) and disease-specific mortality (HR: 2.41, 95% CI: 1.51-3.84, p < 0.001), compared to their South Korean counterparts, even when controlled for age and sex. Comparing the USA to South Korea, the survival differences in all-cause mortality (HR: 1.75, 95% CI: 1.12-2.75, p = 0.015) and disease-specific mortality (HR: 1.94, 95% CI: 1.14-3.31, p = 0.015) were also pronounced. The 3-year disease-specific survival rates in South Korea, the USA, and Chile were 75%, 65%, and 55%, respectively, the 5-year disease-specific survival rates were 60%, 50%, and 50%, respectively, and the overall 5-year survival rates were 55%, 45%, and 35%, respectively. In conclusion, the survival of true T2 GBC in properly classified cases is neither as good nor as bad as previously documented in the literature and shows notable geographic differences even in well-sampled cases with consensus histopathologic criteria. Future studies should focus on other potential reasons including biologic, etiopathogenetic, management-related, populational, or healthcare practice-related factors that may influence the survival differences of T2 GBC in different regions.
dc.fuente.origenWOS
dc.identifier.doi10.1007/s00428-020-02968-5
dc.identifier.eissn1432-2307
dc.identifier.issn0945-6317
dc.identifier.urihttps://doi.org/10.1007/s00428-020-02968-5
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/95085
dc.identifier.wosidWOS:000605899300002
dc.issue.numero5
dc.language.isoen
dc.pagina.final884
dc.pagina.inicio875
dc.revistaVirchows archiv
dc.rightsacceso restringido
dc.subjectGallbladder cancer
dc.subjectTumor staging
dc.subjectSurvival
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleT2 gallbladder cancer shows substantial survival variation between continents and this is not due to histopathologic criteria or pathologic sampling differences
dc.typeartículo
dc.volumen478
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
Files
Collections
Artículos de revistas