An unusual mulinane diterpenoid from the Chilean plant <i>Azorella trifurcata</i> (Gaertn) Pers

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dc.contributor.authorAreche, Carlos
dc.contributor.authorSepulveda, Beatriz
dc.contributor.authorSan Martin, Aurelio
dc.contributor.authorGarcia-Beltran, Olimpo
dc.contributor.authorSimirgiotis, Mario
dc.contributor.authorCanete, Alvaro
dc.date.accessioned2025-01-23T21:48:44Z
dc.date.available2025-01-23T21:48:44Z
dc.date.issued2014
dc.description.abstractFour new mulinane-type diterpenoids besides the known compounds mulin-11,13-dien-20-oic acid, 13 alpha-hydroxyazorellane, 13 beta-hydroxyazorellane, mulinolic acid, azorellanol, and mulin-11,13-dien-18-acetoxy-16,20-dioic acid were isolated from the Chilean plant Azorella trifurcata. One of the new metabolites isolated, 7 alpha-acetoxy-9-epi-13 beta-hydroxymulinane, possesses a new trans-syn-trans arrangement in a tricyclic ring system not previously encountered in nature. Among the mulinane diterpenoids isolated, mulin-11,13-dien-20-oic acid showed the gastroprotective effect on HCl-EtOH-induced gastric lesions in mice (ED50 = 55mg kg(-1)). Regarding the mode of gastroprotective action for this active compound, its effect was reduced by pre-treatment of the mice with indomethacin and N-ethylmaleimide, suggesting that prostaglandins and sulfhydryl compounds are positively involved in the gastroprotective activity using this model.
dc.description.funderFONDECYT INICIACION
dc.fuente.origenWOS
dc.identifier.doi10.1039/c4ob00966e
dc.identifier.eissn1477-0539
dc.identifier.issn1477-0520
dc.identifier.urihttps://doi.org/10.1039/c4ob00966e
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/101763
dc.identifier.wosidWOS:000340437800014
dc.issue.numero33
dc.language.isoen
dc.pagina.final6413
dc.pagina.inicio6406
dc.revistaOrganic & biomolecular chemistry
dc.rightsacceso restringido
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleAn unusual mulinane diterpenoid from the Chilean plant <i>Azorella trifurcata</i> (Gaertn) Pers
dc.typeartículo
dc.volumen12
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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