Non-invasive in vivo imaging of changes in Collagen III turnover in myocardial fibrosis

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dc.article.number33
dc.catalogadorgjm
dc.contributor.authorChaher, Nadia
dc.contributor.authorLacerda, Sara
dc.contributor.authorDigilio, Giuseppe
dc.contributor.authorPadovan, Sergio
dc.contributor.authorGao, Ling
dc.contributor.authorLavín, Begoña
dc.contributor.authorStefania, Rachele
dc.contributor.authorVelasco Jimeno, Carlos
dc.contributor.authorCruz, Gastão
dc.contributor.authorPrieto Vásquez, Claudia
dc.contributor.authorBotnar, René Michael
dc.contributor.authorPhinikaridou, Alkystis
dc.date.accessioned2025-03-13T15:16:44Z
dc.date.available2025-03-13T15:16:44Z
dc.date.issued2024
dc.description.abstractHeart failure (HF) affects 64 million people globally with enormous societal and healthcare costs. Myocardial fibrosis, characterised by changes in collagen content drives HF. Despite evidence that collagen type III (COL3) content changes during myocardial fibrosis, in vivo imaging of COL3 has not been achieved. Here, we discovered the first imaging probe that binds to COL3 with high affinity and specificity, by screening candidate peptide-based probes. Characterisation of the probe showed favourable magnetic and biodistribution properties. The probe’s potential for in vivo molecular cardiac magnetic resonance imaging was evaluated in a murine model of myocardial infarction. Using the new probe, we were able to map and quantify, previously undetectable, spatiotemporal changes in COL3 after myocardial infarction and monitor response to treatment. This innovative probe provides a promising tool to non-invasively study the unexplored roles of COL3 in cardiac fibrosis and other cardiovascular conditions marked by changes in COL3.
dc.fechaingreso.objetodigital2025-03-13
dc.format.extent15 páginas
dc.fuente.origenORCID
dc.identifier.doi10.1038/s44303-024-00037-z
dc.identifier.urihttps://doi.org/10.1038/s44303-024-00037-z
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/102562
dc.information.autorucEscuela de Ingeniería; Prieto Vásquez, Claudia; 0000-0003-4602-2523; 14195
dc.information.autorucEscuela de Ingeniería; Botnar, René Michael; 0000-0003-2811-2509; 1015313
dc.nota.accesocontenido completo
dc.revistanpj Imaging
dc.rightsacceso abierto
dc.rights.licenseCC BY 4.0 Attribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.subject.ods03 Good health and well-being
dc.subject.odspa03 Salud y bienestar
dc.titleNon-invasive in vivo imaging of changes in Collagen III turnover in myocardial fibrosis
dc.typeartículo
dc.volumen2
sipa.codpersvinculados14195
sipa.codpersvinculados1015313
sipa.trazabilidadORCID;2025-03-03
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