Experimental Analyses Emphasize the Stability of the Meisenheimer Complex in a S<sub>N</sub>Ar Reaction Toward Trends in Reaction Pathways

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dc.contributor.authorCampodonico, Paola R.
dc.contributor.authorOlivares, Belen
dc.contributor.authorTapia, Ricardo A.
dc.date.accessioned2025-01-23T19:49:23Z
dc.date.available2025-01-23T19:49:23Z
dc.date.issued2020
dc.description.abstractThe mechanism of SNAr reactions between 2-chloro-5-nitropyrimidine with primary and secondary alicyclic amines, respectively, have been studied by kinetic measurements. The kinetic data obtained in aqueous media opens a controversial discussion based on Bronsted-type plots analysis. The first approach based on the kinetic data reveals a non-catalyzed pathway. Then, the subtlety of the mathematical treatment of the kinetic data is discussed over a concerted or stepwise mechanism, respectively.
dc.description.funderFONDECYT
dc.fuente.origenWOS
dc.identifier.doi10.3389/fchem.2020.00583
dc.identifier.issn2296-2646
dc.identifier.urihttps://doi.org/10.3389/fchem.2020.00583
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/100499
dc.identifier.wosidWOS:000555781600001
dc.language.isoen
dc.revistaFrontiers in chemistry
dc.rightsacceso restringido
dc.subjectSNAr reaction
dc.subjectreaction mechanism
dc.subjectBronsted-type plots
dc.subjectborder mechanisms
dc.subjectMeisenheimer complex
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleExperimental Analyses Emphasize the Stability of the Meisenheimer Complex in a S<sub>N</sub>Ar Reaction Toward Trends in Reaction Pathways
dc.typeartículo
dc.volumen8
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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