Lack of Diagnostic Utility of Specific Immunoglobulin M in Helicobacter pylori Infection in Children

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dc.contributor.authorSerrano, Carolina A.
dc.contributor.authorGonzalez, Carmen G.
dc.contributor.authorRollan, Antonio R.
dc.contributor.authorDuarte, Ignacio
dc.contributor.authorTorres, Javiera
dc.contributor.authorPena, Alfredo J.
dc.contributor.authorHarris, Paul R.
dc.date.accessioned2024-01-10T13:14:15Z
dc.date.available2024-01-10T13:14:15Z
dc.date.issued2008
dc.description.abstractBackground: Helicobacter pylori infection results in ill a systemic immune response characterized by the initial rise of immunoglobulin (Ig) M followed by the elevation of IgG and IgA-specific antibody levels in serum. Age and regional considerations may modify the accuracy of serological tests.
dc.description.abstractObjectives: To determine the accuracy of specific IgG, IgA, and IgM in H pylori infection determination in different age groups. Patients and Methods: We enrolled 179 patients referred for endoscopy. Patients were considered infected if they had positive histological or urease test results for H pylori. Titers of IgG, IgA, and IgM were determined in serum by enzyme-linked immunosorbent assay. Through receiver operator characteristic curves. cutoff, , sensitivity, and specificity values were obtained. Agreement and correlation between immunoglobulin titers and inflammation markers, were explored.
dc.description.abstractResults: Infection with H pylori was present in 58%, of adults, 62% of adolescents, and 25% of children. Sensitivity and specificity were higher in children younger than 12-years old for IgG and IgA. All diagnostic performance values were lower for IgM. Agreement measures were approximately 0.5 in adults and reached values of approximately 0.7 for adolescents and children. IgM had negative agreement with other methods. There was a correlation between inflammation markers, H pylori load, and immunoglobulin titers for IgG and IgA. These associations decreased with age and were not observed for IgM.
dc.description.abstractConclusions: IgG and IgA serological tests reached high performance values, particularly in children younger than 12 years old, indicating that they are reasonable screening methods once cutoff values are adjusted to local population and age. IgM does not present an additional contribution. JPGN 47:612-617, 2008.
dc.description.funderFONDECYT
dc.description.funderNIH
dc.description.funderNATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES
dc.fechaingreso.objetodigital2024-05-22
dc.format.extent6 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1097/MPG.0b013e3181668648
dc.identifier.issn0277-2116
dc.identifier.pubmedidMEDLINE:18979584
dc.identifier.urihttps://doi.org/10.1097/MPG.0b013e3181668648
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/78387
dc.identifier.wosidWOS:000260519400013
dc.information.autorucMedicina;Duarte I;S/I;98528
dc.information.autorucMedicina;González C;S/I;126290
dc.information.autorucMedicina;Harris P;S/I;80706
dc.information.autorucMedicina;Pena A;S/I;75347
dc.information.autorucMedicina;Rollan A;S/I;100118
dc.information.autorucMedicina;Torres J;S/I;95391
dc.issue.numero5
dc.language.isoen
dc.nota.accesocontenido parcial
dc.pagina.final617
dc.pagina.inicio612
dc.publisherLIPPINCOTT WILLIAMS & WILKINS
dc.revistaJOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION
dc.rightsacceso restringido
dc.subjectHelicobacter pylori
dc.subjectSerological diagnosis accuracy
dc.subjectDiagnostic performance
dc.subjectSerology validation
dc.subjectGASTRIC-CANCER
dc.subjectFOLLOW-UP
dc.subjectANTIBODIES
dc.subjectACCURACY
dc.subjectTESTS
dc.subjectSERUM
dc.subjectIMMUNOASSAYS
dc.subjectACQUISITION
dc.subjectPOPULATION
dc.subjectPREVALENCE
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleLack of Diagnostic Utility of Specific Immunoglobulin M in Helicobacter pylori Infection in Children
dc.typeartículo
dc.volumen47
sipa.codpersvinculados98528
sipa.codpersvinculados126290
sipa.codpersvinculados80706
sipa.codpersvinculados75347
sipa.codpersvinculados100118
sipa.codpersvinculados95391
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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