Effects of noninvasive ventilation on lung hyperinflation in stable hypercapnic COPD

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dc.contributor.authorDiaz, O
dc.contributor.authorBegin, P
dc.contributor.authorTorrealba, B
dc.contributor.authorJover, E
dc.contributor.authorLisboa, C
dc.date.accessioned2024-01-10T13:12:37Z
dc.date.available2024-01-10T13:12:37Z
dc.date.issued2002
dc.description.abstractTwo previous uncontrolled studies have suggested that noninvasive mechanical ventilation (NIMV) in patients with hypercapnic chronic obstructive pulmonary disease (COPD) improves arterial blood gas tensions by decreasing lung hyperinflation with the consequent reduction in inspiratory loads and changes in ventilatory pattern. The aim of this randomised placebo-controlled study was to determine whether these mechanisms play a pivotal role in the effects of NIMV on arterial blood gases.
dc.description.abstractThirty-six stable hypercapnic COPD patients were randomly allocated to NIMV or sham NIMV. A 2-week run-in period was followed by a 3-week study period, during which ventilation was applied 3 h-day 1, 5 days a week. Arterial blood gases, spirometry, lung volumes, and respiratory mechanics were measured before and after application of NIMV.
dc.description.abstractPatients submitted to NIMV showed changes (mean (95% confidence interval)) in daytime arterial carbon dioxide tension (Pa,CO2) and arterial oxygen tension of -1.12 (-1.52-0.73) kPa (-8.4 (-11.4-5.5) mmHg) and 1.14 (0.70-1.50) kPa (8.6 (5.3-11.9) mmHg), respectively. Total lung capacity, functional residual capacity (FRC) and residual volume were found to be reduced by 10 (7-13), 25 (18-31), and 36 (27-45)% of their predicted value, respectively, whereas forced expiratory volume in one second and forced vital capacity increased by 4 (1.5-6.9) and 9 (5-13)% pred, respectively. Tidal volume (VT) increased by 181 (110-252) mL. All of the above changes were significant compared with sham NIMV. Changes in Pa,CO2 were significantly related to changes in dynamic intrinsic positive end-expiratory pressure, inspiratory lung impedance, VT and FRC.
dc.description.abstractIt was concluded that the beneficial effects of noninvasive mechanical ventilation could be explained by a reduction in lung hyperinflation and inspiratory loads.
dc.fechaingreso.objetodigital2024-05-15
dc.format.extent9 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1183/09031936.02.00034402
dc.identifier.eissn1399-3003
dc.identifier.issn0903-1936
dc.identifier.pubmedidMEDLINE:12503709
dc.identifier.urihttps://doi.org/10.1183/09031936.02.00034402
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/78210
dc.identifier.wosidWOS:000180064000023
dc.information.autorucMedicina;Díaz O;S/I;78564
dc.information.autorucMedicina;Lisboa C;S/I;98551
dc.issue.numero6
dc.language.isoen
dc.nota.accesocontenido parcial
dc.pagina.final1498
dc.pagina.inicio1490
dc.publisherEUROPEAN RESPIRATORY SOC JOURNALS LTD
dc.revistaEUROPEAN RESPIRATORY JOURNAL
dc.rightsacceso restringido
dc.subjectchronic obstructive pulmonary disease
dc.subjecthypercapnia
dc.subjectnoninvasive mechanical ventilation
dc.subjectpulmonary rehabilitation
dc.subjectrespiratory mechanics
dc.subjectNEGATIVE-PRESSURE VENTILATION
dc.subjectOBSTRUCTIVE PULMONARY-DISEASE
dc.subjectEND-EXPIRATORY PRESSURE
dc.subjectMECHANICAL VENTILATION
dc.subjectREDUCTION SURGERY
dc.subjectCONTROLLED-TRIAL
dc.subjectFLOW LIMITATION
dc.subjectSUPPORT
dc.subjectIMPROVEMENT
dc.subjectDIAPHRAGM
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleEffects of noninvasive ventilation on lung hyperinflation in stable hypercapnic COPD
dc.typeartículo
dc.volumen20
sipa.codpersvinculados78564
sipa.codpersvinculados98551
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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