Bilateral oophorectomy in a pregnant woman

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dc.contributor.authorVillaseca, P
dc.contributor.authorCampino, C
dc.contributor.authorOestreicher, E
dc.contributor.authorMayerson, D
dc.contributor.authorSerón-Ferré, M
dc.contributor.authorArteaga, E
dc.date.accessioned2025-01-21T01:07:11Z
dc.date.available2025-01-21T01:07:11Z
dc.date.issued2005
dc.description.abstractBackground: A 16 week pregnant woman presented with massive theca-lutein cysts requiring bilateral oophorectomy. Pregnancy progressed uneventfully and spontaneous lactation ensued after delivery. Methods: To study the role of the ovary on the hormonal profile at the end of gestation and in post-partum, we measured FSH, estradiol (E-2), unconjugated estrone (E-1), unconjugated estriol (E-3), sex hormone-binding globulin, progesterone, dehydroepiandrosterone sulphate and prolactin at 37 weeks gestation and at 8 h, 4 days, 5 weeks, and 2 months post-partum. Results: These hormones were within the range expected for ovary-intact pregnant and puerperal women until 4 days post-partum. At 5 weeks post-partum, FSH increased to a peri-menopausal range (31.4 IU/l) while estrogens remained within the normal puerperal range (E-2=239 pmol/l; E-1=102 pmol/l), contrasting with their rapid changes in non-pregnant women after bilateral oophorectomy. At 2 months, while partially breastfeeding, FSH, E-2 and E-1 were closer to menopausal range (68 IU/l, 136 and 70.2 pmol/l respectively), and hormone replacement was started. Conclusions: We conclude that the ovary is not required to maintain a normal hormonal profile in late pregnancy and early puerperium. However, the increase in FSH to peri-menopausal levels at 5 weeks post-partum, despite breastfeeding, suggests that the ovary is needed to maintain low FSH concentrations during lactation.
dc.fuente.origenWOS
dc.identifier.doi10.1093/humrep/deh597
dc.identifier.eissn1460-2350
dc.identifier.issn0268-1161
dc.identifier.urihttps://doi.org/10.1093/humrep/deh597
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/96290
dc.identifier.wosidWOS:000226611300012
dc.issue.numero2
dc.language.isoen
dc.pagina.final401
dc.pagina.inicio397
dc.revistaHuman reproduction
dc.rightsacceso restringido
dc.subjectbilateral ovariectomy
dc.subjectestrogens
dc.subjectFSH
dc.subjectpregnancy
dc.subjectpremature menopause
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleBilateral oophorectomy in a pregnant woman
dc.typeartículo
dc.volumen20
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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