BCG-induced cross-protection and development of trained immunity: implication for vaccine design

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dc.article.number2806
dc.catalogadorpva
dc.contributor.authorCovián, Camila
dc.contributor.authorFernández Fierro, Ayleen Lorena
dc.contributor.authorRetamal Díaz, Angello Ricardo
dc.contributor.authorDíaz Acevedo, Fabián Esteban
dc.contributor.authorVásquez Veloso, Abel
dc.contributor.authorLay Remolcoi, Margarita Kam-len
dc.contributor.authorRiedel Soria, Claudia
dc.contributor.authorGonzález Muñoz, Pablo Alberto
dc.contributor.authorBueno Ramírez, Susan
dc.contributor.authorKalergis Parra, Alexis Mikes
dc.date.accessioned2024-01-24T14:30:24Z
dc.date.available2024-01-24T14:30:24Z
dc.date.issued2019
dc.description.abstractThe Bacillus Calmette-Guerin (BCG) is a live attenuated tuberculosis vaccine that has the ability to induce non-specific cross-protection against pathogens that might be unrelated to the target disease. Vaccination with BCG reduces mortality in newborns and induces an improved innate immune response against microorganisms other than Mycobacterium tuberculosis, such as Candida albicans and Staphylococcus aureus. Innate immune cells, including monocytes and natural killer (NK) cells, contribute to this non-specific immune protection in a way that is independent of memory T or B cells. This phenomenon associated with a memory-like response in innate immune cells is known as "trained immunity." Epigenetic reprogramming through histone modification in the regulatory elements of particular genes has been reported as one of the mechanisms associated with the induction of trained immunity in both, humans and mice. Indeed, it has been shown that BCG vaccination induces changes in the methylation pattern of histones associated with specific genes in circulating monocytes leading to a "trained" state. Importantly, these modifications can lead to the expression and/or repression of genes that are related to increased protection against secondary infections after vaccination, with improved pathogen recognition and faster inflammatory responses. In this review, we discuss BCG-induced cross-protection and acquisition of trained immunity and potential heterologous effects of recombinant BCG vaccines.
dc.description.funderVRAID (ex DIPUC)
dc.fechaingreso.objetodigital2024-01-24
dc.fuente.origenHistorial Académico
dc.identifier.citationRetamal Diaz Angello Ricardo, Díaz Acevedo Fabián Esteban, Lay Remolcoi Margarita Kam-Len, Gonzalez Munoz Pablo Alberto, Bueno Ramirez Susan Marcela, Kalergis Parra Alexis Mikes. BCG-Induced Cross-Protection and Development of Trained Immunity : Implication for Vaccine Design. 2019;10
dc.identifier.doi10.3389/fimmu.2019.02806
dc.identifier.issn1664-3224
dc.identifier.urihttps://doi.org/10.3389/fimmu.2019.02806
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/80931
dc.identifier.wosidWOS:000502780600001
dc.information.autorucFacultad de Ciencias Biológicas; Fernández Fierro, Ayleen Lorena; S/I; 1126909
dc.information.autorucFacultad de Ciencias Biológicas; Retamal Díaz, Angello Ricardo; 0000-0002-8840-1911; 225150
dc.information.autorucFacultad de Ciencias Biológicas; Díaz Acevedo, Fabián Esteban; S/I; 1050268
dc.information.autorucFacultad de Ciencias Biológicas; Lay Remolcoi, Margarita Kam-len; S/I; 90429
dc.information.autorucFacultad de Ciencias Biológicas; Riedel Soria, Claudia; S/I; 88772
dc.information.autorucFacultad de Ciencias Biológicas; González Muñoz, Pablo Alberto; 0000-0001-7709-6870; 15616
dc.information.autorucFacultad de Ciencias Biológicas; Bueno Ramírez, Susan; 0000-0002-7551-8088; 113541
dc.information.autorucFacultad de Ciencias Biológicas; Kalergis Parra, Alexis Mikes; 0000-0001-7622-5263; 90610
dc.language.isoen
dc.nota.accesoContenido completo
dc.pagina.final14
dc.pagina.inicio1
dc.revistaFrontiers in Immunologyes_ES
dc.rightsacceso abierto
dc.rights.licenseCreative Commons Attribution License (CC BY)
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectBCGes_ES
dc.subjectInnate immunityes_ES
dc.subjectTrained immunityes_ES
dc.subjectHeterologous protectiones_ES
dc.subjectVaccinees_ES
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleBCG-induced cross-protection and development of trained immunity: implication for vaccine designes_ES
dc.typeartículo de revisión
dc.volumen10
sipa.codpersvinculados1126909
sipa.codpersvinculados225150
sipa.codpersvinculados1050268
sipa.codpersvinculados90429
sipa.codpersvinculados88772
sipa.codpersvinculados15616
sipa.codpersvinculados113541
sipa.codpersvinculados90610
sipa.trazabilidadHistorial Académico;09-07-2021
sipa.trazabilidadORCID;2024-01-15
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