A Pooled Analysis to Compare the Clinical Characteristics of Human Papillomavirus-positive and -Negative Cervical Precancers

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dc.contributor.authorCastle, Philip E.
dc.contributor.authorPierz, Amanda J.
dc.contributor.authorAdcock, Rachael
dc.contributor.authorAslam, Shagufta
dc.contributor.authorBasu, Partha S.
dc.contributor.authorBelinson, Jerome L.
dc.contributor.authorCuzick, Jack
dc.contributor.authorEl-Zein, Mariam
dc.contributor.authorFerreccio, Catterina
dc.contributor.authorFirnhaber, Cynthia
dc.contributor.authorFranco, Eduardo L.
dc.contributor.authorGravitt, Patti E.
dc.contributor.authorIsidean, Sandra D.
dc.contributor.authorLin, John
dc.contributor.authorMahmud, Salaheddin M.
dc.contributor.authorMonsonego, Joseph
dc.contributor.authorMuwonge, Richard
dc.contributor.authorRatnam, Samuel
dc.contributor.authorSafaeian, Mahboobeh
dc.contributor.authorSchiffman, Mark
dc.contributor.authorSmith, Jennifer S.
dc.contributor.authorSwarts, Avril
dc.contributor.authorWright, Thomas C.
dc.contributor.authorVan De Wyngard, Vanessa
dc.contributor.authorXi, Long Fu
dc.date.accessioned2025-01-23T19:47:46Z
dc.date.available2025-01-23T19:47:46Z
dc.date.issued2020
dc.description.abstractGiven that high-risk human papillomavirus (HPV) is the necessary cause of virtually all cervical cancer, the clinical meaning of HPV-negative cervical precancer is unknown. We, therefore, conducted a literature search in Ovid MEDLINE, PubMed Central, and Google Scholar to identify English-language studies in which (i) HPV-negative and -positive, histologically confirmed cervical intraepithelial neoplasia grade 2 or more severe diagnoses (CIN2+) were detected and (ii) summarized statistics or deidentified individual data were available to summarize proportions of biomarkers indicating risk of cancer. Nineteen studies including 3,089 (91.0%) HPV-positive and 307 (9.0%) HPV-negative CIN2+ were analyzed. HPV-positive CIN2+ (vs. HPV-negative CIN2+) was more likely to test positive for biomarkers linked to cancer risk: a study diagnosis of CIN3+ (vs. CIN2; 18 studies; 0.56 vs. 0.24; P < 0.001) preceding high-grade squamous intraepithelial lesion cytology (15 studies; 0.54 vs. 0.10; P < 0.001); and high-grade colposcopic impression (13 studies; 0.30 vs. 0.18; P = 0.03). HPV-negative CIN2+ was more likely to test positive for low-risk HPV genotypes than HPV-positive CIN2+ (P < 0.001). HPV-negative CIN2+ appears to have lower cancer risk than HPV-positive CIN2+. Clinical studies of human high-risk HPV testing for screening to prevent cervical cancer may refer samples of HPV test-negative women for disease ascertainment to correct verification bias in the estimates of clinical performance. However, verification bias adjustment of the clinical performance of HPV testing may overcorrect/underestimate its clinical performance to detect truly precancerous abnormalities.
dc.description.funderCanada Research Chairs Program
dc.fuente.origenWOS
dc.identifier.doi10.1158/1940-6207.CAPR-20-0182
dc.identifier.eissn1940-6215
dc.identifier.issn1940-6207
dc.identifier.urihttps://doi.org/10.1158/1940-6207.CAPR-20-0182
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/100407
dc.identifier.wosidWOS:000576794700004
dc.issue.numero10
dc.language.isoen
dc.pagina.final840
dc.pagina.inicio829
dc.revistaCancer prevention research
dc.rightsacceso restringido
dc.subject.ods03 Good Health and Well-being
dc.subject.ods05 Gender Equality
dc.subject.odspa03 Salud y bienestar
dc.subject.odspa05 Igualdad de género
dc.titleA Pooled Analysis to Compare the Clinical Characteristics of Human Papillomavirus-positive and -Negative Cervical Precancers
dc.typeartículo
dc.volumen13
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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