Targeting eosinophils in respiratory diseases: biological axis, emerging therapeutics and treatment modalities

Simple item page
dc.article.number118973
dc.catalogadorpva
dc.contributor.authorLee, L.-Y.
dc.contributor.authorHew, G.S.Y.
dc.contributor.authorMehta, M.
dc.contributor.authorShukla, S.D.
dc.contributor.authorSatija, S.
dc.contributor.authorKhurana, N.
dc.contributor.authorAnand, K.
dc.contributor.authorDureja, H.
dc.contributor.authorSingh, S.K.
dc.contributor.authorMishra, V.
dc.contributor.authorSingh, P.K.
dc.contributor.authorGulati, M.
dc.contributor.authorPrasher, P.
dc.contributor.authorAljabali, A.A.A.
dc.contributor.authorTambuwala, M.M.
dc.contributor.authorThangavelu, L.
dc.contributor.authorPanneerselvam, J.
dc.contributor.authorGupta, G.
dc.contributor.authorZacconi, Flavia C. M.
dc.contributor.authorShastri, M.
dc.contributor.authorJha, N.K.
dc.contributor.authorXenaki, D.
dc.contributor.authorMacLoughlin, R.
dc.contributor.authorOliver, B.G.
dc.contributor.authorChellappan, D.K.
dc.contributor.authorDua, K.
dc.date.accessioned2023-08-23T21:08:33Z
dc.date.available2023-08-23T21:08:33Z
dc.date.issued2021
dc.description.abstractEosinophils are bi-lobed, multi-functional innate immune cells with diverse cell surface receptors that regulate local immune and inflammatory responses. Several inflammatory and infectious diseases are triggered with their build up in the blood and tissues. The mobilization of eosinophils into the lungs is regulated by a cascade of processes guided by Th2 cytokine generating T-cells. Recruitment of eosinophils essentially leads to a characteristic immune response followed by airway hyperresponsiveness and remodeling, which are hallmarks of chronic respiratory diseases. By analysing the dynamic interactions of eosinophils with their extracellular environment, which also involve signaling molecules and tissues, various therapies have been invented and developed to target respiratory diseases. Having entered clinical testing, several eosinophil targeting therapeutic agents have shown much promise and have further bridged the gap between theory and practice. Moreover, researchers now have a clearer understanding of the roles and mechanisms of eosinophils. These factors have successfully assisted molecular biologists to block specific pathways in the growth, migration and activation of eosinophils. The primary purpose of this review is to provide an overview of the eosinophil biology with a special emphasis on potential pharmacotherapeutic targets. The review also summarizes promising eosinophil-targeting agents, along with their mechanisms and rationale for use, including those in developmental pipeline, in clinical trials, or approved for other respiratory disorders.
dc.description.funderFONDECYT
dc.fechaingreso.objetodigital2023-08-23
dc.fuente.origenHistorial Académico
dc.identifier.citationLi-Yen Lee, Geena Suet Yin Hew, Meenu Mehta, Shakti D. Shukla, Saurabh Satija, Navneet Khurana, Krishnan Anand, Harish Dureja, Sachin Kumar Singh, Pankaj Kumar Singh, Monica Gulati, Parteek Prasher, Alaa A.A. Aljabali, Murtaza M. Tambuwala, Lakshmi Thangavelu, Jithendra Panneerselvam, Gaurav Gupta, Kamal Dua. Targeting eosinophils in respiratory diseases: Biological axis, emerging therapeutics and treatment modalities. Life Sciences. 2021;267(118973):1-1.
dc.identifier.doi10.1016/j.lfs.2020.118973
dc.identifier.issn0024-3205
dc.identifier.scopusidSCOPUS_ID:2-s2.0-85099161908
dc.identifier.urihttps://doi.org/10.1016/j.lfs.2020.118973
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/74482
dc.identifier.wosidWOS:000613297100045
dc.information.autorucEscuela de Química; Zacconi, Flavia C. M.; 0000-0002-3676-0453; 1011127
dc.language.isoen
dc.nota.accesoContenido parcial
dc.pagina.final26
dc.pagina.inicio1
dc.revistaLife Scienceses_ES
dc.rightsacceso restringido
dc.subjectRespiratory diseaseses_ES
dc.subjectPulmonaryes_ES
dc.subjectEosinophilses_ES
dc.subjectTargeted therapieses_ES
dc.subjectImmunityes_ES
dc.subjectLunges_ES
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleTargeting eosinophils in respiratory diseases: biological axis, emerging therapeutics and treatment modalitieses_ES
dc.typeartículo
dc.volumen267
sipa.codpersvinculados1011127
sipa.indexISI-1991-1993-1999-2000-2006
sipa.indexPubmed
sipa.trazabilidadHistorial Académico;09-07-2021
sipa.trazabilidadConveris;20-07-2021
sipa.trazabilidadORCID;2023-08-21
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Targeting_eosinophils_in_respiratory_diseases.pdf
Size:
62.97 KB
Format:
Adobe Portable Document Format
Description:
Download
Collections
Artículos de revistas