Modulation of tumor immunity by soluble and membrane-bound molecules at the immunological synapse

Simple item page
dc.article.number450291
dc.catalogadoraba
dc.contributor.authorGonzález, P.A.
dc.contributor.authorCarreño, L.J.
dc.contributor.authorCéspedes, P.F.
dc.contributor.authorBueno, S.M.
dc.contributor.authorRiedel, C.A.
dc.contributor.authorKalergis, A.M.
dc.date.accessioned2024-03-04T15:19:43Z
dc.date.available2024-03-04T15:19:43Z
dc.date.issued2013
dc.description.abstractTo circumvent pathology caused by infectious microbes and tumor growth, the host immune system must constantly clear harmful microorganisms and potentially malignant transformed cells. This task is accomplished in part by T-cells, which can directly kill infected or tumorigenic cells. A crucial event determining the recognition and elimination of detrimental cells is antigen recognition by the T cell receptor (TCR) expressed on the surface of T cells. Upon binding of the TCR to cognate peptide-MHC complexes presented on the surface of antigen presenting cells (APCs), a specialized supramolecular structure known as the immunological synapse (IS) assembles at the T cell-APC interface. Such a structure involves massive redistribution of membrane proteins, including TCR/pMHC complexes, modulatory receptor pairs, and adhesion molecules. Furthermore, assembly of the immunological synapse leads to intracellular events that modulate and define the magnitude and characteristics of the T cell response. Here, we discuss recent literature on the regulation and assembly of IS and the mechanisms evolved by tumors to modulate its function to escape T cell cytotoxicity, as well as novel strategies targeting the IS for therapy.
dc.fechaingreso.objetodigital2024-05-27
dc.format.extent19 páginas
dc.fuente.origenORCID
dc.identifier.doi10.1155/2013/450291
dc.identifier.issn1740-2522
dc.identifier.urihttps://doi.org/10.1155/2013/450291
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/82476
dc.language.isoen
dc.nota.accesoContenido completo
dc.pagina.final20
dc.pagina.inicio1
dc.revistaClinical and Developmental Immunology
dc.rightsacceso abierto
dc.rights.licenseCC BY 3.0 DEED Attribution 3.0 Unported
dc.rights.urihttps://creativecommons.org/licenses/by/3.0/
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.titleModulation of tumor immunity by soluble and membrane-bound molecules at the immunological synapse
dc.typeartículo de revisión
dc.volumen2013
sipa.codpersvinculados113541
sipa.trazabilidadORCID;2024-01-15
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Modulation of Tumor Immunity.pdf
Size:
3.21 MB
Format:
Adobe Portable Document Format
Description:
Download
Collections
Artículos de revistas