Anthocyanins from aristotelia chilensis prevent olanzapine-induced hepatic-lipid accumulation but not insulin resistance in skeletal muscle cells

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dc.article.number6149
dc.contributor.authorDel Campo A.
dc.contributor.authorSalamanca C.
dc.contributor.authorFajardo A.
dc.contributor.authorBustos C.
dc.contributor.authorCalfio C.
dc.contributor.authorAcuna-Castillo C.
dc.contributor.authorRojo L.E.
dc.contributor.authorDel Campo A.
dc.contributor.authorDiaz-Castro F.
dc.contributor.authorTroncoso R.
dc.contributor.authorTroncoso R.
dc.contributor.authorPastene-Navarrete E.R.
dc.contributor.authorMilla L.A.
dc.contributor.authorVillarroel C.A.
dc.contributor.authorCubillos F.A.
dc.contributor.authorVillarroel C.A.
dc.contributor.authorCubillos F.A.
dc.contributor.authorAranda M.
dc.date.accessioned2024-01-10T12:37:09Z
dc.date.available2024-01-10T12:37:09Z
dc.date.issued2021
dc.description.abstract© 2021 by the authors. Licensee MDPI, Basel, Switzerland.Type 2 diabetes and obesity are major problems worldwide and dietary polyphenols have shown efficacy to ameliorate signs of these diseases. Anthocyanins from berries display potent antioxidants and protect against weight gain and insulin resistance in different models of diet-induced metabolic syndrome. Olanzapine is known to induce an accelerated form of metabolic syndrome. Due to the aforementioned, we evaluated whether delphinidin-3,5-O-diglucoside (DG) and delphinidin-3-O-sambubioside-5-O-glucoside (DS), two potent antidiabetic anthocyanins isolated from Aristotelia chilensis fruit, could prevent olanzapine-induced steatosis and insulin resistance in liver and skeletal muscle cells, respectively. HepG2 liver cells and L6 skeletal muscle cells were co-incubated with DG 50 µg/mL or DS 50 µg/mL plus olanzapine 50 µg/mL. Lipid accumulation was determined in HepG2 cells while the expression of p-Akt as a key regulator of the insulin-activated signaling pathways, mitochondrial function, and glucose uptake was assessed in L6 cells. DS and DG prevented olanzapine-induced lipid accumulation in liver cells. However, insulin signaling impairment induced by olanzapine in L6 cells was not rescued by DS and DG. Thus, anthocyanins modulate lipid metabolism, which is a relevant factor in hepatic tissue, but do not significantly influence skeletal muscle, where a potent antioxidant effect of olanzapine was found.
dc.description.funderANID
dc.description.funderDICYT 021943AC
dc.description.funderDesarrollo e Innovaci?n
dc.description.funderUni-versidad de Santiago de Chile
dc.description.funderFONDECYT
dc.fechaingreso.objetodigital2024-05-23
dc.fuente.origenScopus
dc.identifier.doi10.3390/molecules26206149
dc.identifier.eissn14203049
dc.identifier.issn14203049
dc.identifier.pubmedid34684731
dc.identifier.scopusidSCOPUS_ID:85117514756
dc.identifier.urihttps://doi.org/10.3390/molecules26206149
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/76767
dc.information.autorucFacultad de Química y de Farmacia; Aranda Bustos, Mario Antonio; S/I; 1103178
dc.issue.numero20
dc.language.isoen
dc.nota.accesoContenido completo
dc.publisherMDPI
dc.relation.ispartofMolecules
dc.revistaMolecules
dc.rightsacceso abierto
dc.subjectAkt phosphorylation
dc.subjectAnthocyanins
dc.subjectInsulin resistance
dc.subjectLipid accumulation
dc.subjectMitochondrial oxygen consumption
dc.titleAnthocyanins from aristotelia chilensis prevent olanzapine-induced hepatic-lipid accumulation but not insulin resistance in skeletal muscle cells
dc.typeartículo
dc.volumen26
sipa.codpersvinculados1103178
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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