Trypanosoma cruzi: Activities of lapachol and alpha- and beta-lapachone derivatives against epimastigote and trypomastigote forms

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dc.contributor.authorSalas, Cristian
dc.contributor.authorTapia, Ricardo A.
dc.contributor.authorCiudad, Karina
dc.contributor.authorArmstrong, Veronica
dc.contributor.authorOrellana, Myriam
dc.contributor.authorKemmerling, Ulrike
dc.contributor.authorFerreira, Jorge
dc.contributor.authorMaya, Juan Diego
dc.contributor.authorMorello, Antonio
dc.date.accessioned2024-01-10T12:10:26Z
dc.date.available2024-01-10T12:10:26Z
dc.date.issued2008
dc.description.abstractDerivatives of natural quinones with biological activities, such as lapachol, alpha- and beta-lapachones, have been synthesized and their trypanocidal activity evaluated in vitro in Trypanosoma cruzi cells. All tested compounds inhibited epimastigote growth and trypomastigote viability. Several compounds showed similar or higher activity as compared with current trypanocidal drugs, nifurtimox and benznidazole. The results presented here show that the anti-T Cruzi activity of the alpha-lapachone derivatives can be increased by the replacement of the benzene ring by a pyridine moiety. Free radical production and consequently oxidative stress through redox cycling or production of electrophilic metabolites are the potential biological mechanism of action for these synthetic quinones. (c) 2007 Elsevier Ltd. All rights reserved.
dc.fechaingreso.objetodigital21-03-2024
dc.format.extent7 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1016/j.bmc.2007.10.038
dc.identifier.issn0968-0896
dc.identifier.pubmedidMEDLINE:18029184
dc.identifier.urihttps://doi.org/10.1016/j.bmc.2007.10.038
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/76577
dc.identifier.wosidWOS:000253581500006
dc.information.autorucQuímica;Armstrong V ;S/I;64737
dc.information.autorucQuímica;Ciudad K;S/I;17786
dc.information.autorucQuímica;Salas C;S/I;101425
dc.information.autorucQuímica;Tapia RA ;S/I;47801
dc.issue.numero2
dc.language.isoen
dc.nota.accesocontenido parcial
dc.pagina.final674
dc.pagina.inicio668
dc.publisherPERGAMON-ELSEVIER SCIENCE LTD
dc.revistaBIOORGANIC & MEDICINAL CHEMISTRY
dc.rightsacceso restringido
dc.subjectTRYPANOCIDAL ACTIVITY
dc.subjectSUPEROXIDE ANION
dc.subjectNAPHTHOQUINONES
dc.subjectNAPHTHO<2,3-B>PYRANOQUINONES
dc.subjectNITROIMIDAZOLE
dc.subjectINTERMEDIATE
dc.subjectCHEMOTHERAPY
dc.subjectINHIBITOR
dc.subjectINVITRO
dc.subjectANALOGS
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleTrypanosoma cruzi: Activities of lapachol and alpha- and beta-lapachone derivatives against epimastigote and trypomastigote forms
dc.typeartículo
dc.volumen16
sipa.codpersvinculados64737
sipa.codpersvinculados17786
sipa.codpersvinculados101425
sipa.codpersvinculados47801
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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